Double-blind trial of linoleate supplementation of the diet in multiple sclerosis.
J. H. D. Millar,K. J. Zilkha,M. J. S. Langman,H. P. Wright,A. D. Smith,J. Belin,R. H. S. Thompson +6 more
TLDR
Relapses tended to be less frequent and be significantly less severe and of shorter duration in the linoleate-supplemented group than in those receiving the oleate mixture, but clear evidence that treatment affected the overall rate of clinical deterioration was not obtained.Abstract:
Seventy-five patients in London and Belfast with multiple sclerosis were given daily supplements of a vegetable oil mixture containing either linoleate or oleate for two years in a double-blind control trial Relapses tended to be less frequent and were significantly less severe and of shorter duration in the linoleate-supplemented group than in those receiving the oleate mixture, but clear evidence that treatment affected the overall rate of clinical deterioration was not obtainedread more
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Journal ArticleDOI
Reduction in saturated fat intake for cardiovascular disease
TL;DR: There was some evidence that reducing saturated fats reduced the risk of myocardial infarction, but effects on all-cause mortality and cardiovascular morbidity were less clear, and there were suggestions of greater protection with greater saturated fat reduction or greater increase in polyunsaturated and monounsaturated fats.
Journal ArticleDOI
Reduced or modified dietary fat for preventing cardiovascular disease
Lee Hooper,Carolyn Summerbell,Rachel Thompson,Deirdre Sills,Felicia G. Roberts,Helen J Moore,George Davey Smith +6 more
TL;DR: The findings are suggestive of a small but potentially important reduction in cardiovascular risk on modification of dietary fat, but not reduction of total fat, in longer trials.
Journal ArticleDOI
Cytokine secretion and eicosanoid production in the peripheral blood mononuclear cells of MS patients undergoing dietary supplementation with n-3 polyunsaturated fatty acids
Virgilio Gallai,Paola Sarchielli,Alberto Trequattrini,Maristella Franceschini,Ardesio Floridi,Caterina Firenze,Andrea Alberti,Daniela Di Benedetto,Eduardo Stragliotto +8 more
TL;DR: In this paper, the influence of n-3 PUFA supplementation on cytokine and eicosanoid production in peripheral blood mononuclear cells (PBMCs) of MS patients (MSP) was investigated.
Book ChapterDOI
Fatty Acids and Immunity
TL;DR: Increased turnover of phospholipid fatty acids, following lymphocyte stimulation, requires a transferase to incorporate new fatty acids and a means of generating lysophosphatides and free fatty acids as substrates for this enzyme.
Journal ArticleDOI
Efficacy and toxicity of cyclosporine in chronic progressive multiple sclerosis: A randomized, double-blinded, placebo-controlled clinical trial
TL;DR: Chronic cyclosporine therapy was associated with a statistically significant but clinically modest delay of progression of disability in a group of patients with multiple sclerosis selected for moderately severe and progressive disease.
References
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Proceedings of the Royal Society of Medicine
TL;DR: The primary function is no doubt to be an aid in grasping anatomy, normal and malformed, and the book is good: it is clear and balanced and well based on modern descriptive work, though, since the vigilance of no writer is perfect, some refining of careless statements will naturally be needed in later editions.
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On the evaluation of disability in multiple sclerosis
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Journal ArticleDOI
Myelin constituents of human central nervous system.
Jørgen Clausen,Inge Berg Hansen +1 more
TL;DR: Recently, accounts have been presented of the complete quantitativc distribution of membrane constituents in grey matter, white matter, and in myelin and other subcellular particulate fractions of the central nervous system (CNS) (survey by Mokrasch 1969, Rouser & Yarriainoto 1969, Clausen 1969).
Journal ArticleDOI
Multiple sclerosis: twenty years on low fat diet.
TL;DR: The author's experience in treating cases of multiple sclerosis with a low fat diet for more than 20 years is assessed, both in treatment of the data and in conclusions.