Journal ArticleDOI
Effect of low saturated fat diet in early and late cases of multiple sclerosis
Roy L. Swank,B. Brewer Dugan +1 more
TLDR
Patients who adhered to the prescribed low-fat diet showed significantly less deterioration and much lower death rates than did those who consumed more fat than prescribed.About:
This article is published in The Lancet.The article was published on 1990-07-07. It has received 183 citations till now.read more
Citations
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Journal ArticleDOI
Environmental factors and multiple sclerosis
TL;DR: Studies in Canada have provided strong evidence that environmental factors act at a population level to influence the unusual geographical distribution of multiple sclerosis, but the available data accommodate more than one type of environmental effect.
Journal ArticleDOI
Obesity predisposes to Th17 bias.
Shawn Winer,Geoff Paltser,Yin Chan,Hubert Tsui,Edgar G. Engleman,Daniel A. Winer,H.-Michael Dosch +6 more
TL;DR: It is demonstrated that obesity selectively promotes an expansion of the Th17 T‐cell sublineage, a subset with prominent pro‐inflammatory roles, which is mechanistically linked to a Th17 bias.
Journal ArticleDOI
Cytokine secretion and eicosanoid production in the peripheral blood mononuclear cells of MS patients undergoing dietary supplementation with n-3 polyunsaturated fatty acids
Virgilio Gallai,Paola Sarchielli,Alberto Trequattrini,Maristella Franceschini,Ardesio Floridi,Caterina Firenze,Andrea Alberti,Daniela Di Benedetto,Eduardo Stragliotto +8 more
TL;DR: In this paper, the influence of n-3 PUFA supplementation on cytokine and eicosanoid production in peripheral blood mononuclear cells (PBMCs) of MS patients (MSP) was investigated.
Environmental risk factors for multiple sclerosis
TL;DR: A large number of those diagnosed with multiple sclerosis believe that the disease should be treated as a single disease rather than a collection of symptoms that affect a person's daily life.
Journal ArticleDOI
Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brains
Jimmy L. Huynh,Paras Garg,Tin Htwe Thin,Seungyeul Yoo,Ranjan Dutta,Bruce D. Trapp,Vahram Haroutunian,Jun Zhu,Michael J. Donovan,Andrew J. Sharp,Patrizia Casaccia +10 more
TL;DR: Genes regulating oligodendrocyte survival, such as BCL2L2 and NDRG1, were hypermethylated and expressed at lower levels in multiple sclerosis–affected brains than in controls, while genes related to proteolytic processing were hypomethylated and expression at higher levels.
References
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Journal ArticleDOI
Rating neurologic impairment in multiple sclerosis An expanded disability status scale (EDSS)
TL;DR: A new Expanded Disability Status Scale (EDSS) is presented, with each of the former steps (1,2,3 … 9) now divided into two (1.0, 1.5, 2.0 … 9).
Journal ArticleDOI
Multiple sclerosis in rural Norway its geographic and occupational incidence in relation to nutrition.
TL;DR: The investigation of the distribution of cases of multiple sclerosis in Switzerland between the years 1918 and 1922 seems to have established that the frequency of this disease can vary greatly in different geographic locations.
Journal ArticleDOI
Multiple sclerosis: Decreased relapse rate through dietary supplementation with calcium, magnesium and vitamin D
TL;DR: The dietary regimen may offer a new means of controlling the exacerbation rate in MS, at least for younger patients, and tends to support a theory of MS which states that calcium and magnesium are important in the development, structure and stability of myelin.
Journal ArticleDOI
Double-blind trial of linoleate supplementation of the diet in multiple sclerosis.
J. H. D. Millar,K. J. Zilkha,M. J. S. Langman,H. P. Wright,A. D. Smith,J. Belin,R. H. S. Thompson +6 more
TL;DR: Relapses tended to be less frequent and be significantly less severe and of shorter duration in the linoleate-supplemented group than in those receiving the oleate mixture, but clear evidence that treatment affected the overall rate of clinical deterioration was not obtained.