Journal ArticleDOI
Drug disposition and drug hypersensitivity.
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This article is published in Biochemical Pharmacology.The article was published on 1987-03-01. It has received 197 citations till now.read more
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Anticonvulsant hypersensitivity syndrome. In vitro assessment of risk.
N H Shear,S P Spielberg +1 more
TL;DR: Arene oxide metabolites of aromatic anticonvulsants (phenytoin, phenobarbital, and carbamazepine) may be involved in the pathogenesis of hypersensitivity reactions and cells from patients' parents exhibited in vitro toxicity that was intermediate between values for controls and patients.
Journal ArticleDOI
Acyl glucuronides revisited: is the glucuronidation process a toxification as well as a detoxification mechanism?
TL;DR: Acyl glucuronides Revisited: Is the Glucuronidation Proces a Toxification as well as a Detoxification Mechanism? Drug Metabolism Reviews: Vol. 24, No. 1, pp. 5-47 as mentioned in this paper.
Journal ArticleDOI
Fortnightly review: Adverse drug reactions
TL;DR: The current status of adverse drug reactions is reviewed, briefly describing the complexity of the more bizarre reactions and outlining a strategy to eliminate serious adversedrug reactions.
Journal ArticleDOI
Toxic epidermal necrolysis (Lyell syndrome)
TL;DR: Accumulated clinical evidence points to drugs as the most important, if not the only, cause of toxic epidermal necrolysis.
Journal ArticleDOI
Idiosyncratic adverse reactions to antiepileptic drugs.
TL;DR: Idiosyncratic drug reactions may be defined as adverse effects that cannot be explained by the known mechanisms of action of the offending agent, do not occur at any dose in most patients, and develop mostly unpredictably in susceptible individuals only.
References
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Journal Article
Further studies of the human platelet receptor for quinine- and quinine-dependent antibodies.
TL;DR: The results strongly suggest that the receptor for quinine- and quinidine-dependent antibodies is associated with GP lb and/or its high m.w. structural analog(s).
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Detection of serum IgE antibodies that react with alcuronium and tubocurarine after life-threatening reactions to muscle-relaxant drugs.
Brian A. Baldo,M. McD. Fisher +1 more
TL;DR: High levels of drug-specific IgE antibodies in the sera of some subjects who reacted to these muscle relaxants are found, providing important supporting evidence that, in some patients at least, lifethreatening anaphylactoid reactions to muscle-relaxant drugs are mediated by drug- specific Ig E antibodies.
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Antigenicity and Cross-Reactivity of Penicillins and Cephalosporins
TL;DR: It is clear that there is extensive heterogeneity in cross-reactivity to homologous penicilloyl determinants among different sera or individuals having BPO-specific antibodies.
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The biliary and urinary metabolites of [3H]17 alpha-ethynylestradiol in women.
TL;DR: The metabolism of 17α-ethynyl[6,7-3H]estradiol (3H-EE2) given orally was studied in two groups of women in order to identify conjugated biliary and urinary fractions and the metabolites excreted were largely polar conjugates.
Journal ArticleDOI
Anaphylactoid reactions in dialysis patients: role of ethylene-oxide.
TL;DR: To determine whether anaphylactoid reactions during dialysis are the result of allergy to ethylene oxide (EtO) used for sterilisation of dialysis equipment, EtO-specific cytophilic antibodies on basophils were detected by means of a sensitive protease-release assay.
Related Papers (5)
Anticonvulsant hypersensitivity syndrome. In vitro assessment of risk.
N H Shear,S P Spielberg +1 more