Journal ArticleDOI
Drug disposition and drug hypersensitivity.
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This article is published in Biochemical Pharmacology.The article was published on 1987-03-01. It has received 197 citations till now.read more
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Induction of apoptosis in breast cancer cells by naphthylisoquinoline alkaloids.
Prem Prakash Kushwaha,Atul Kumar Singh,Kumari Sunita Prajapati,Mohd Shuaib,Shaimaa Fayez,Gerhard Bringmann,Shashank Kumar +6 more
TL;DR: Mechanistic investigations revealed that all of the three substances induce apoptotic cell death via its intrinsic pathway by causing deformation of the nuclear membrane, disruption of the mitochondrial membrane potential (MMP), and elevated reactive oxygen species (ROS) production in both cell lines.
Journal ArticleDOI
Suppression of T-lymphocyte proliferation by sulphonamide hydroxylamines.
TL;DR: The hydroxylamine of sulfamethoxazole produces profound suppression of T-lymphocyte proliferation, which may explain the infectious complications contributing to mortality associated with sulphonamide hypersensitivity reactions.
Journal ArticleDOI
Mechanism of hypersensitivityreactions: proposed involvement of reactive metabolites generated by activated leukocytes
TL;DR: Jack Uetrecht explains that the pattern of hypersensitivity reactions associated with these drugs - drug-induced lupus, agranulocytosis, and generalized hypers sensitivity reactions - fits a mechanism in which leukocyte-generated reactive metabolites initiate the hypersensitivity reaction.
Journal ArticleDOI
Cellular toxicity of sulfamethoxazole reactive metabolites—I: Inhibition of intracellular esterase activity prior to cell death
TL;DR: It is concluded that SMX-HA inhibition of intracellular esterase activity is an early event in the process that terminates in metabolite-induced cell death and is responsible for the observed loss of cellular fluorescence after drug exposure.
Journal ArticleDOI
Allergic reactions to cytotoxic drugs―an update
Mary O'Brien,B. E. Souberbielle +1 more
References
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Journal Article
Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.
Journal ArticleDOI
Studies on the sensitization of animals with simple chemical compounds
Karl Landsteiner,John Jacobs +1 more
TL;DR: Experiments on the sensitization of guinea pigs with simple chemical compounds are described, with positive effects obtained by the administration of small quantities with 1:2:4 chlorodinitrobenzene, p-nitrosodimethylaniline, and a number of other aromatic compounds.
Journal ArticleDOI
Immune-complex glomerulopathy in patients treated with captopril
TL;DR: Renal biopsies were performed on 13 patients treated with captopril and findings indicated an early stage of membranous glomerulopathy (MGP), which may be associated with the development of immune-complex glomerULopathy.
Journal ArticleDOI
Antibodies to the surface of halothane-altered rabbit hepatocytes in patients with severe halothane-associated hepatitis.
Diego Vergani,Giorgina Mieli-Vergani,A. Alberti,James Neuberger,Adrian L. W. F. Eddleston,Michael Davis,Roger Williams +6 more
TL;DR: Control studies using serum from subjects repeatedly exposed to halothane without the development of liver damage, and from patients with viral and toxic liver injury have confirmed the specificity of these findings to serve Halothane-associated liver injury.
Journal ArticleDOI
Biochemical Mechanisms in Chemical-Induced Lung Injury: Roles of Metabolic Activation
Michael R. Boyd,H.P. Witschi +1 more
TL;DR: In this paper, the role of metabolic activation in Chemical-Induced Lung Injury was discussed and a detailed review of the biochemical mechanism of lung injury was presented. But this paper focused on lung injury.
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