Journal ArticleDOI
Drug disposition and drug hypersensitivity.
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This article is published in Biochemical Pharmacology.The article was published on 1987-03-01. It has received 197 citations till now.read more
Citations
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Journal ArticleDOI
The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity
TL;DR: Avoidance of toxicity may be possible in rare instances by prediction of individual susceptibility or by designing new chemical entities that are metabolised by a range of enzymes (both cytochromes P450 and others) and do not undergo bioactivation.
Journal ArticleDOI
Liquid chromatography-electrospray mass spectrometry determination of carbamazepine, oxcarbazepine and eight of their metabolites in human plasma.
Hélène Breton,Marylène Cociglio,Françoise Bressolle,Hélène Peyrière,J.-P. Blayac,Dominique Hillaire-Buys +5 more
TL;DR: A specific and sensitive liquid chromatography-electrospray ionization mass spectrometry method was described for the simultaneous determination of carbamazepine, oxcarbazepine and eight of their metabolites in human plasma and found suitable for the analysis of plasma samples collected during therapeutic drug monitoring of patients treated with CBZ or OXCBZ.
Journal ArticleDOI
Immunological principles of adverse drug reactions: the initiation and propagation of immune responses elicited by drug treatment.
TL;DR: The purpose of this review is to classify drug hypersensitivity reactions in terms of their clinical presentation, and to consider recent advances in the understanding of the chemical, biochemical and cellular immunological mechanisms of hypersensitivity.
Journal ArticleDOI
Cytochrome P450 1B1: a major P450 isoenzyme in human blood monocytes and macrophage subsets
Jens M. Baron,Gabriele Zwadlo-Klarwasser,Frank K. Jugert,W. Hamann,Albert Rübben,Hasan Mukhtar,Hans F. Merk +6 more
TL;DR: The expression of several CYPs in monocytes/macrophages suggests that these cells may be important in the metabolism of small molecular weight compounds, which play a role in allergic contact dermatitis and drug reactions.
Book ChapterDOI
The danger hypothesis applied to idiosyncratic drug reactions.
Jinze Li,Jack Uetrecht +1 more
TL;DR: No one model fits the characteristics of all idiosyncratic drug reactions; however, the danger model provides a new perspective and suggests avenues of research that have the potential to increase the ability to predict and prevent such reactions significantly.
References
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Journal Article
Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.
Journal ArticleDOI
Studies on the sensitization of animals with simple chemical compounds
Karl Landsteiner,John Jacobs +1 more
TL;DR: Experiments on the sensitization of guinea pigs with simple chemical compounds are described, with positive effects obtained by the administration of small quantities with 1:2:4 chlorodinitrobenzene, p-nitrosodimethylaniline, and a number of other aromatic compounds.
Journal ArticleDOI
Immune-complex glomerulopathy in patients treated with captopril
TL;DR: Renal biopsies were performed on 13 patients treated with captopril and findings indicated an early stage of membranous glomerulopathy (MGP), which may be associated with the development of immune-complex glomerULopathy.
Journal ArticleDOI
Antibodies to the surface of halothane-altered rabbit hepatocytes in patients with severe halothane-associated hepatitis.
Diego Vergani,Giorgina Mieli-Vergani,A. Alberti,James Neuberger,Adrian L. W. F. Eddleston,Michael Davis,Roger Williams +6 more
TL;DR: Control studies using serum from subjects repeatedly exposed to halothane without the development of liver damage, and from patients with viral and toxic liver injury have confirmed the specificity of these findings to serve Halothane-associated liver injury.
Journal ArticleDOI
Biochemical Mechanisms in Chemical-Induced Lung Injury: Roles of Metabolic Activation
Michael R. Boyd,H.P. Witschi +1 more
TL;DR: In this paper, the role of metabolic activation in Chemical-Induced Lung Injury was discussed and a detailed review of the biochemical mechanism of lung injury was presented. But this paper focused on lung injury.
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