Patent
Dual variable domain immunoglobulins and uses thereof
TLDR
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.Abstract:
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.read more
Citations
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Patent
Bivalent, bispecific antibodies
TL;DR: In this article, the present invention relates to novel domain exchanged, bivalent, bispecific antibodies, their manufacture and use, and their use relates to the use of domain exchange.
Patent
Treatment of cancer using humanized anti-cd19 chimeric antigen receptor
TL;DR: In this paper, the authors provide compositions and methods for treating diseases associated with expression of CD19, including methods of administering a genetically modified T cell expressing a chimeric antigen receptor (CAR) that comprises a CD19 binding domain.
Patent
Covalent Diabodies and Uses Thereof
Leslie S. Johnson,Ling Huang +1 more
TL;DR: In this paper, the diabody molecules of the present invention comprise two polypeptide chains that associate to form at least two epitope binding sites, which may recognize the same or different epitopes on different or differing antigens.
Patent
Antibody molecules to pd-1 and uses thereof
Gordon J. Freeman,Arlene H. Sharpe,Walter A. Blattler,Jennifer Marie Mataraza,Catherine Anne Sabatos-Peyton,Chang Hwai Wen,Frey Gerhard Johann +6 more
TL;DR: In this article, the anti-PD-1 antibody molecules can be used to treat, prevent and diagnose cancerous or infectious conditions and disorders, and they can be found to specifically bind to PD-1.
References
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Book
Molecular Cloning: A Laboratory Manual
TL;DR: Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years as mentioned in this paper and has been so popular, or so influential, that no other manual has been more widely used and influential.
Book
Antibodies: A Laboratory Manual
Ed Harlow,David P. Lane +1 more
TL;DR: A second edition of Antibodies: A Laboratory Manual is being published in September 2013, Revised, extended and updated by Edward Greenfield of the Dana-Farber Cancer Center, the material has been recast with extensive new information and new chapters have been added.
Journal ArticleDOI
A simple method for displaying the hydropathic character of a protein
Jack Kyte,Russell F. Doolittle +1 more
TL;DR: A computer program that progressively evaluates the hydrophilicity and hydrophobicity of a protein along its amino acid sequence has been devised and its simplicity and its graphic nature make it a very useful tool for the evaluation of protein structures.
Journal ArticleDOI
Continuous cultures of fused cells secreting antibody of predefined specificity
G Köhler,C. Milstein +1 more
TL;DR: The derivation of a number of tissue culture cell lines which secrete anti-sheep red blood cell (SRBC) antibodies is described here, made by fusion of a mouse myeloma and mouse spleen cells from an immunised donor.