Early detection of malignancy in ulcerative colitis. A flow-cytometric DNA study.
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TLDR
The cellular DNA content in colorectal biopsies from 51 patients with chronic ulcerative colitis has been studied with flow‐cytometric technique and aneuploid cell lines were found in eight patients, two of which had histopathologically verified malignancies.Abstract:
The cellular DNA content in colorectal biopsies from 51 patients with chronic ulcerative colitis has been studied with flow-cytometric technique. The DNA pattern has been related to the duration of the disease, and to histopathology. Aneuploid cell lines were found in eight patients, two of which had histopathologically verified malignancies. Aneuploid cell lines were found in 2% of biopsies from mucosa classified as normal, in 10% of biopsies with inflammation, hyperplasia or atrophy, in 25% of polyps and in biopsies with dysplasia and in seven of eight biopsies from adenocarcinomas. Four of 27 cases with 11 to 20 years duration of disease, and 4 of 10 with more than 20 years disease, had aneuploid cell lines. Combined with colonoscopy the flow-cytometric technique can routinely be used in the follow-up of patients with ulcerative colitis in screening for malignant cell lines.read more
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References
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Local complications of ulcerative colitis: stricture, pseudopolyposis, and carcinoma of colon and rectum.
TL;DR: Because of disordered function of the temporal lobe, which may be related to disorder of structure when morphological study is available, it follows that even though the lesion may be a small one the patient is brain-damaged, to use a topical phrase.
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Cancer in Colitis: Assessment of the Individual Risk by Clinical and Histological Criteria
TL;DR: A scheme of management for patients with extensive colitis, including regular rectal and colonic biopsies, is proposed and it is suggested that a small group of patients who require surgical treatment for established precancerous change or carcinoma with a high likelihood of cure will be isolated.