Journal ArticleDOI
Eclamptogenic toxemia: The development of an experimental model in the subhuman primate
TLDR
Findings lend over-all support to the view that it is possible to develop a “toxemia model” in the subhuman primate.About:
This article is published in American Journal of Obstetrics and Gynecology.The article was published on 1974-09-15. It has received 44 citations till now. The article focuses on the topics: Blood coagulation test.read more
Citations
More filters
Journal ArticleDOI
Pathophysiology of hypertension during preeclampsia: linking placental ischemia with endothelial dysfunction
Jeffrey S. Gilbert,Michael J. Ryan,Babbette B Lamarca,Mona Sedeek,Sydney R. Murphy,Joey P. Granger +5 more
TL;DR: Identifying the connection between placental ischemia/hypoxia and maternal cardiovascular abnormalities in hopes of revealing potential therapeutic regimens remains an important area of investigation and will be the focus of this review.
Journal ArticleDOI
Pathophysiology of hypertension during preeclampsia linking placental ischemia with endothelial dysfunction.
TL;DR: Results from ongoing basic and clinical studies should provide new and important information regarding the physiological mechanisms responsible for the elevation in arterial pressure in women with preeclampsia.
Journal ArticleDOI
Pathophysiology of preeclampsia: linking placental ischemia/hypoxia with microvascular dysfunction.
TL;DR: While recent studies support a role for cytokines and other factors such as lipid peroxides and reactive oxygen intermediates as potential mediators of endothelial dysfunction, finding the link between placental ischemia/hypoxia and maternal endothelial and vascular abnormalities remains an important area of investigation.
Journal ArticleDOI
Animal models of preeclampsia.
TL;DR: Because this disease only occurs spontaneously in primates, the definitive studies on preeclampsia will, of necessity, be clinical, and the preeclamptic-like response of rats with adriamycin nephropathy and hyperinsulinemia is associated with endothelial dysfunction.
Book ChapterDOI
Reduced uterine perfusion pressure (RUPP) model for studying cardiovascular-renal dysfunction in response to placental ischemia.
Joey P. Granger,Babbette LaMarca,Kathy Cockrell,Mona Sedeek,Charles Balzi,Derrick Chandler,William A. Bennett +6 more
TL;DR: This chapter details the methods the laboratory uses to produce the reduced uterine perfusion pressure (RUPP) model in the pregnant rat, the most promising animal model to study potential mechanisms of preeclampsia.
References
More filters
Book
Textbook of Medical Physiology
Arthur C. Guyton,John E. Hall +1 more
TL;DR: Textbook of medical physiology , Textbook ofmedical physiology , کتابخانه دیجیتال جندی شاپور اهواز
Journal ArticleDOI
Textbook of Medical Physiology
TL;DR: Textbook of medical physiology, Textbook of Medical Physiology, this paper, textbook of medicine, textbooks of medical science, text book of medical literature, textbook medical physiology.
Journal ArticleDOI
The Partial Thromboplastin Time with Kaolin: A Simple Screening Test for First Stage Plasma Clotting Factor Deficiencies
TL;DR: Waaler has demonstrated that long times with normal plasma may be caused by inadequate contact activation of the test plasma when, and it is shown that the partial thromboplastin time technic is not widely used in clinical laboratories.
Journal ArticleDOI
Thrombokinetics in man
TL;DR: Platelet production, distribution, and destruction have been quantitated in normal man and in selected patients with platelet disorders and, in most instances, total production as calculated from the megakaryocyte mass agreed with production estimated from platelet turnover.
Journal ArticleDOI
The mechanism of clot dissolution by plasmin
TL;DR: The results indicate that since plasminogen is found both in plasma and also as a constituent of thrombi, clot lysis occurs by a dual mechanism.