Journal ArticleDOI
Effect of 6-aminonicotinamide on monoamine oxidase and Na+K+ATPase activity in different regions of rat brain
TLDR
The monoamine oxidase activity in the cerebral hemispheres decreased significantly after 2, 4, 8 and 16 hr of 6-amino-nicotinamide administration, while in the cerebellum, the MAO activity was not affected significantly and the Na+K+ATPase activity did not change significantly.About:
This article is published in Biochemical Pharmacology.The article was published on 1984-10-01. It has received 3 citations till now. The article focuses on the topics: Monoamine oxidase & Na+/K+-ATPase.read more
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Journal ArticleDOI
Neurotoxin 6-aminonicotinamide affects levels of soluble proteins and enzyme activities in various tissues of golden hamsters.
TL;DR: The results suggest that the changes in levels of soluble proteins and enzyme activities shown with golden hamster tissues by 6-AN administration were quite different from those shown with quail tissues.
Journal ArticleDOI
6-Aminonicotinamide: EEG changes and effects on the activities of enzymes related to glutamate metabolism in rat brain regions.
TL;DR: The results indicate that glutamate metabolism offers considerable anaplerotic potentials following impaired energy state after 6-AN treatment, and shows opposite pattern of changes in cerebellum, whereas cerebral hemispheres and brain stem exhibited similar response.
Journal ArticleDOI
M-signal hypothesis — metabolic modulation of membrane functions in rat brain
TL;DR: M-signal hypothesis is proposed, which attempts at explaining the regulation of plasma membrane function by the intermediate of metabolic processes in the cell by exercising its influence on the plasma membrane Na+/K+ ATPase which is responsible for the uptake process.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
The monoamine oxidase inhibitors clorgyline and l-deprenyl also affect the uptake of dopamine, noradrenaline and serotonin by rat brain synaptosomal preparations
TL;DR: The observation that clorgyline is a more specific inhibitor of the uptake of serotonin (a type AMAO substrate) is consistent with its activity as a type A MAO inhibitor.
Journal ArticleDOI
Cerebral energy reserves and glycolysis in neural tissue of 6-aminonicotinamide-treated mice.
F. C. Kauffman,E. C. Johnson +1 more
TL;DR: Cerebral energy metabolism was studied in brains of mice treated with the nicotinamide analog, 6-aminonicotinamide (6-AN), which is converted to a potent inhibitor of 6-phosphogluconate dehydrogenase in viro, and normal cerebral energy use was maintained during the initial period of anoxic-ischemia.
Journal ArticleDOI
Changes in monoamine oxidase activity in rat brain during alloxan diabetes.
TL;DR: It was observed that monoamine oxidase activity was decreased at early time intervals after diabetes, followed by a recovery in all three regions of the brain after diabetes.
Journal ArticleDOI
Na+,K+-ATPase and Mg2+-ATPase activities in different regions of rat brain during alloxan diabetes.
TL;DR: It was observed that Na2+,K2+‐ATPase activity increased at early time intervals after diabetes, followed by a recovery to near control levels in all three regions of the brain.