Effect of epidermal growth factor on lung maturation in fetal rabbits.
William Zack Catterton,Marilyn Escobedo,William R. Sexson,Mary E. Gray,Hakan Sundell,Mildred T. Stahlman +5 more
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Injection of epidermal growth factor into 24-day rabbit fetuses (5 μg, im or ip) induced accelerated maturation of the lung and may be an important hormone in the maturation and capable of protecting the prematurely delivered fetus against the development of hyaline membrane disease.Abstract:
Summary: Injection of epidermal growth factor (EGF) into 24-day rabbit fetuses (5 μg, im or ip) induced accelerated maturation of the lung. On sacrifice at day 27, there was greater distensibility and stability on deflation associated with the appearance of a complement of type II cells approaching that of the rabbit at term. EGF treatment had no demonstrable effect on body weight or lung weight in this group of animals. Saline-injected control fetuses were not affected significantly.read more
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Epidermal growth factor
TL;DR: The EGF-MolecularWeight Form of mEGF and the Synthesis of Extracellular Macromolecules, and the Biological Effects of EGF and Urogastrone are presented.
Journal ArticleDOI
Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor
Päivi J. Miettinen,Joel E. Berger,Juanito J. Meneses,Yume Phung,Roger A. Pedersen,Zena Werb,Rik Derynck +6 more
TL;DR: It is found that EGF-R-/- mice survive for up to 8 days after birth and suffer from impaired epithelial development in several organs, including skin, lung and gastrointestinal tract.
Journal ArticleDOI
Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast
Eric P. Sandgren,Noreen C. Luetteke,Richard D. Palmiter,Ralph L. Brinster,David C. Lee,David C. Lee +5 more
TL;DR: Metallothionein-directed expression of TGF alpha in transgenic mice induced a spectrum of changes in the growth and differentiation of certain adult tissues and displays characteristics of both a potent epithelial cell mitogen and an oncogenic protein in vivo.
Journal ArticleDOI
The type 1 (EGFR-related) family of growth factor receptors and their ligands.
TL;DR: The involvement of these receptors and growth factors in human cancer has implications for the design of novel forms of therapy for cancer, and recent advances and future avenues for investigation are reviewed.
Journal ArticleDOI
Epidermal growth factor is a major growth-promoting agent in human milk.
TL;DR: The results identify epidermal growth factor as a major growth-promoting agent in breast milk and its role in mitogenic activity is identified.
References
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THE USE OF LEAD CITRATE AT HIGH pH AS AN ELECTRON-OPAQUE STAIN IN ELECTRON MICROSCOPY
TL;DR: The stain reported here differs from previous alkaline lead stains in that the chelating agent, citrate, is in sufficient excess to sequester all lead present, and is less likely to contaminate sections.
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Improvements in epoxy resin embedding methods.
TL;DR: Epoxy embedding methods of Glauert and Kushida have been modified so as to yield rapid, reproducible, and convenientembedding methods for electron microscopy.
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Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born Animal
TL;DR: The isolation of the factor responsible for the earlier development of the incisors and eyelids is reported here, a heat-stable, nondialysable, antigenic protein, whose most distinctive chemical characteristic is the absence of phenylalanine and lysine.
Journal ArticleDOI
The stimulation of epidermal proliferation by a specific protein (EGF).
TL;DR: The growth-stimulating effects of a protein isolated from the submaxillary gland of the mouse on cultures of both intact skin and separated epidermal sheets derived from the chick embryo have been examined.
Journal ArticleDOI
Accelerated appearance of pulmonary surfactant in the fetal rabbit.
R V Kotas,M E Avery +1 more
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