Journal ArticleDOI
Effect of Immunization Against Rubella on Lactation Products. II. Maternal-Neonatal Interactions
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TLDR
Observations provide strong support for the communicability of rubella virus to neonates via the process of breast-feeding.Abstract:
The transmission of rubella virus to newborn infants via the process of breast-feeding was studied after immunization of 16 breast-feeding and 10 non-breast-feeding mothers with HPV-77 DE5 live, attenuated rubella virus vaccine administered subcutaneously or RA 27/3 live, attenuated rubella virus vaccine administered intranasally or subcutaneously in the immediate postpartum period. Infectious rubella virus or virus antigen was observed in the breast milk of 11 (68%) of the 16 vaccinated, breast-feeding women studied. After maternal immunization, infectious rubella virus or virus antigen was recovered from the nasopharynx and throat of 56% of the breast-fed infants and from none of the non-breast-fed infants. Of the breast-fed infants, 25% showed transient seroconversion to rubella virus but without any clinical disease. No rubella virus-specific seroconversion was observed in the non-breast-fed infants. These observations provide strong support for the communicability of rubella virus to neonates via the process of breast-feeding.read more
Citations
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2013 IDSA Clinical Practice Guideline for Vaccination of the Immunocompromised Host
Lorry G. Rubin,Myron J. Levin,Per Ljungman,E. Graham Davies,Robin K. Avery,Marcie Tomblyn,Athos Bousvaros,Shireesha Dhanireddy,Lillian Sung,Harry L. Keyserling,Insoo Kang +10 more
TL;DR: An international panel of experts prepared an evidenced-based guideline for vaccination of immunocompromised adults and children intended for use by primary care and subspecialty providers who care for immuno-compromised patients.
Journal ArticleDOI
Executive Summary: 2013 IDSA Clinical Practice Guideline for Vaccination of the Immunocompromised Host
Lorry G. Rubin,Myron J. Levin,Per Ljungman,Per Ljungman,E. Graham Davies,Robin K. Avery,Marcie Tomblyn,Athos Bousvaros,Shireesha Dhanireddy,Lillian Sung,Harry L. Keyserling,Insoo Kang +11 more
TL;DR: An international panel of experts prepared an evidenced-based guideline for vaccination of immunocompromised adults and children intended for use by primary care and subspecialty providers who care for immuno-compromised patients.
Journal ArticleDOI
Measles-mumps-rubella vaccine and autistic spectrum disorder: report from the New Challenges in Childhood Immunizations Conference convened in Oak Brook, Illinois, June 12-13, 2000.
Neal A. Halsey,Susan L. Hyman +1 more
TL;DR: The available evidence does not support the hypothesis that MMR vaccine causes autism or associated disorders or IBD, and epidemiologic studies in Europe indicate no association between MMR vaccine and ASD.
Journal ArticleDOI
Postpartum Rubella Immunization: Association with Development of Prolonged Arthritis, Neurological Sequelae, and Chronic Rubella Viremia
TL;DR: Six women developed chronic long-term arthropathy after postpartum immunization against rubella and have had continuing chronic or recurrent arthralgia or arthritis for two to seven years after vaccination.
Journal ArticleDOI
Human Milk and Breast Feeding: an Update on the State of the Art
Pearay L. Ogra,Harry L. Greene +1 more
TL;DR: This discussion summarizes existing information about infant nutrition and immunobiologic aspects of human milk, which may influence the choice of breast versus bottle feeding of infants in different parts of the world.
References
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Immunochemical quantitation of antigens by single radial immunodiffusion
TL;DR: By standardizing the technical conditions of the experiment it is possible to use this principle for the immunochemical determination of antigens, and the lower limit of the method was found to correspond to 0·0025 μg of antigen, and to an antigen concentrations of 1·25 μg per ml.
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Immunofluorescent studies of the development of pre-B cells, B lymphocytes and immunoglobulin isotype diversity in humans
TL;DR: During fetal life, lower concentrations of anti‐y antibodies were required for modulation of sIgM from B lymphocytes of fetal liver and adult bone marrow than for equivalent removal from circulating B cells of mature individuals.
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Antibody Response in Serum and Nasopharynx after Naturally Acquired and Vaccine-Induced Infection with Rubella Virus
TL;DR: Antibody response to rubella virus was studied in serum and nasopharyngeal secretions after natural infection, intranasal inoculation with RA-27/3 rubella vaccine and subcutaneous administration of HPV-77 DK/12 rubella-virus vaccine.
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Immunologic aspects of human colostrum and milk: II. Characteristics of lymphocyte reactivity and distribution of E-rosette forming cells at different times after the onset of lactation**
S.S. Ogra,P.L. Ogra +1 more
TL;DR: The distribution of T-lymphocytes and other cells and proliferative activity to a variety of bacterial and viral antigens was studied in colostrum and milk and peripheral blood of postpartum subjects at various times after the onset of lactation as mentioned in this paper.
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Role of macrophages in immunological maturation.
TL;DR: Very high doses of macrophages are less effective in stimulating antibody synthesis to SRBC than doses of 5 or 10 million, suggesting that a critical ratio ofmacrophages to immunocompetent cells may be required for enhancing antibody synthesis in young mice.