Effect of Ultrasound-Enhanced Transdermal Drug Delivery Efficiency of Nanoparticles and Brucine.
TLDR
This work will provide supportive data on how the brucine is better used for transdermal drug delivery (TDD) and show that under ultrasonic conditions, the permeability of the skin to the fluorescent label and bru cine is increased compared to its passive diffusion permeability.Abstract:
Brucine is the active component in traditional Chinese medicine “Ma-Qian-Zi” (Strychnos nux-vomica Linn), with capabilities of analgesic, anti-inflammatory, anti-tumor and so on. It is crucial how to break through the impact of cuticle skin which reduces the penetration of drugs to improve drug transmission rate. The aim of this study is to improve the local drug concentration by using ultrasound. We used fresh porcine skin to study the effects of ultrasound on the transdermal absorption of brucine under the influence of various acoustic parameters, including frequency, amplitude and irradiation time. The transdermal conditions of yellow-green fluorescent nanoparticles and brucine in skin samples were observed by laser confocal microscopy and ultraviolet spectrophotometry. The results show that under ultrasonic conditions, the permeability of the skin to the fluorescent label and brucine (e.g., the depth and concentration of penetration) is increased compared to its passive diffusion permeability. The best ultrasound penetration can make the penetration depth of more than 110 microns, fluorescent nanoparticles and brucine concentration increased to 2-3 times. This work will provide supportive data on how the brucine is better used for transdermal drug delivery (TDD).read more
Citations
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A Novel Brucine Gel Transdermal Delivery System Designed for Anti-Inflammatory and Analgesic Activities.
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Advances in Ultrasound Mediated Transdermal Drug Delivery.
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Advancement of Lipid-Based Nanocarriers and Combination Application with Physical Penetration Technique
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Transdermal Delivery of Therapeutic Compounds With Nanotechnological Approaches in Psoriasis
Ning Li,Yu Qin,Dan Dai,Peng Wang,Mingfei Shi,Junwei Gao,Jinsheng Yang,Wei Xiao,Ping Song,Ruodan Xu +9 more
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References
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Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the Stratum Corneum
TL;DR: The progress and current status of the transdermal drug delivery field is detailed, numerous pharmaceutical developments which have been employed to overcome limitations associated with skin delivery systems are described and particular attention is paid to the emerging field of microneedle technologies.
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TL;DR: There remains a need to better understand the physics of cavitation of microbubbles and the impact that such cavitation has on cells and drug-carrying vesicle and makes cell membranes and capillaries more permeable to drugs.
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TL;DR: Mechanistic insights gained through a number of investigations are also reviewed, and reports on the synergistic effect of low-frequency ultrasound with other enhancers including chemicals and iontophoresis are summarized.
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An Investigation of the Role of Cavitation in Low-Frequency Ultrasound-Mediated Transdermal Drug Transport
TL;DR: The study showed definitively that ultrasound-induced cavitation is the key mechanism via which LFS permeabilizes the skin, and transient cavitation occurring on, or in the vicinity of, the skin membrane is the central mechanism that is responsible for the observed enhancement of skin permeability by LFS.
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The correlation between acoustic cavitation and sonoporation involved in ultrasound-mediated DNA transfection with polyethylenimine (PEI) in vitro.
TL;DR: Results indicated that IC activity should play an important role in the US-mediated DNA transfection through sonoporation, and ICD could be used as an effective tool to monitor and control theUS-mediated gene/drug delivery effect.
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