Journal ArticleDOI
Advances in Ultrasound Mediated Transdermal Drug Delivery.
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TLDR
The effect of ultrasound on skin integrity and the regulatory requirements for commercialization of the ultrasound based transdermal delivery instruments are summarized.Abstract:
Low frequency ultrasound-assisted drug delivery has been widely investigated as a non-invasive method to enhance the transdermal penetration of drugs. Using this technique, a brief application of ultrasound is used to permeabilize skin for a prolonged time. In this review, an overview on ultrasound is detailed to help explain the parameters that could be modulated to obtain the desired ultrasound parameters for enhanced transdermal drug delivery. The mechanisms of enhancement and the latest developments in the area of ultrasound-assisted transdermal drug delivery are discussed. Special emphasis is placed on the effects of ultrasound when used in combination with microneedles, electroporation and iontophoresis, and penetration enhancers. Further, this review summarizes the effect of ultrasound on skin integrity and the regulatory requirements for commercialization of the ultrasound based transdermal delivery instruments.read more
Citations
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Journal ArticleDOI
Microneedle-Mediated Vaccination: Innovation and Translation.
TL;DR: In this article, a review of the development and application of microneedles for vaccination based on different delivery strategies is presented, and the potential for its application including opportunities and challenges are further discussed.
Journal ArticleDOI
Transdermal Delivery of Chemotherapeutics: Strategies, Requirements, and Opportunities.
Rabin Neupane,Sai H.S. Boddu,Mariam Sami Abou-Dahech,Rinda Devi Bachu,David Terrero,R. Jayachandra Babu,Amit K. Tiwari +6 more
TL;DR: In this paper, the authors discuss the advantages of transdermal route over oral and parenteral routes for popular chemotherapeutic drugs and also discuss a possible in silico approach, Formulating for Efficacy™, to design trans-dermal formulations that would probably be economical, robust, and more efficacious.
Journal ArticleDOI
Transdermal Delivery of Therapeutic Compounds With Nanotechnological Approaches in Psoriasis
Ning Li,Yu Qin,Dan Dai,Peng Wang,Mingfei Shi,Junwei Gao,Jinsheng Yang,Wei Xiao,Ping Song,Ruodan Xu +9 more
TL;DR: This review aims to distinguish the benefits and weaknesses of individual nanostructures when applied as topical antipsoriatics in preclinical psoriatic models and proposes that a proper combination of distinctive nanomaterials according to the physicochemical properties of loaded drugs and clinical features of psoratic patients is becoming a promising option.
Journal ArticleDOI
Transdermal delivery for gene therapy
Parbeen Singh,I’jaaz Muhammad,Nicole E. Nelson,Khanh Thi My Tran,Tra Vinikoor,Meysam T. Chorsi,Ethan D’Orio,Thanh D. Nguyen +7 more
TL;DR: A review of transdermal gene delivery methods for applications in skin cancer treatment, vaccination, wound healing, and other therapies is presented in this paper , where the authors systematically summarize the transderm gene delivery method for applications such as skin cancer, vaccination and wound healing.
Journal ArticleDOI
Multifunctional Inverse Opal Microneedle Arrays for Drug Delivery and Monitoring.
TL;DR: By measuring the wavelength shift value of the IOMNs, the amount of released drugs can be monitored, providing essential guidance for efficient clinical treatment, indicating that the I OMNs are valuable smart drug delivery systems in personalized therapy.
References
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The STARTEC Decision Support Tool for Better Tradeoffs between Food Safety, Quality, Nutrition, and Costs in Production of Advanced Ready-to-Eat Foods
Taran Skjerdal,Andras Gefferth,Miroslav Spajic,Edurne Gaston Estanga,Alessandra De Cesare,Silvia Vitali,Frederique Pasquali,Federica Bovo,Gerardo Manfreda,Rocco Mancusi,Marcello Trevisiani,Girum Tadesse Tessema,Tone Mathisen Fagereng,Lena Haugland Moen,Lars Lyshaug,Anastasios Koidis,Gonzalo Delgado-Pando,Alexandros Ch. Stratakos,Marco Boeri,Cecilie From,Hyat Syed,Mirko Muccioli,Roberto Mulazzani,Catherine Halbert +23 more
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Journal ArticleDOI
Ultrasound-mediated transdermal protein delivery.
TL;DR: Low-frequency ultrasound was shown to increase the permeability of human skin to many drugs, including high molecular weight proteins, by several orders of magnitude, thus making transdermal administration of these molecules potentially feasible.
Journal ArticleDOI
Ultrasound—biophysics mechanisms
TL;DR: In this article, the authors discuss the mechanisms responsible for how ultrasound and biological materials interact and discuss the risk of exposure to these mechanisms in the context of diagnostic ultrasound exposure risk concerns.
PatentDOI
Transdermal protein delivery using low-frequency sonophoresis
TL;DR: In this article, a method for simultaneous application of ultrasound and protein on the skin surface in order to deliver therapeutic doses of proteins across the skin was proposed, which can enhance transdermal transport of high-molecular weight proteins.