Journal ArticleDOI
Effectiveness of first-line antiretroviral therapy in HIV/AIDS patients: A 5-year longitudinal evaluation in Fujian Province, Southeast China.
Shouli Wu,Shouli Wu,Yuefeng Qiu,Pingping Yan,Wei Wang,Meirong Xie,Pincang Xia,Zhenghua Wang,Yansheng Yan,Yansheng Yan +9 more
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TLDR
Long-term antiretroviral therapy remains effective for treatment of HIV/AIDS, resulting in higher mean body weight, effective viral inhibition and a higher CD4 count and a positive correlation between immunological effectiveness and viral inhibition.Abstract:
The aim of this study was to evaluate the long-term effectiveness of first-line antiretroviral therapy in HIV/AIDS patients in Southeast China. A total of 450 eligible patients were selected to initiate first-line antiretroviral therapy from February 2005 through August 2009. During the study period from 2009 through 2013, each subject received clinical and laboratory monitoring for effectiveness, safety and toxicity once every 3 months in the first year, and once every 6 months in the following years. The response to first-line antiretroviral therapy was evaluated through body weight gain and immunological and virological outcomes. During the mean follow-up period of 70.86 ± 28.9 months, the overall mortality was 14.2%. The mean body weight and CD4(+) counts increased significantly following antiretroviral therapy as compared to baselines across the follow-up period, and the rate of immunological effectiveness was over 85% in all subjects at 2 to 5 years of treatment. The rate of inhibition of HIV virus was 87.67%, 89.32%, 91.73%, 92.8% and 91.63% across the study period. In addition, significant differences were detected after treatment as compared to baselines, and Pearson correlation analysis revealed a positive correlation between immunological effectiveness and viral inhibition. Forty-eight percent of the subjects changed antiretroviral drugs once, and 16.22% twice, and 31 patients switched from first-line to second-line antiretroviral therapy. Long-term antiretroviral therapy remains effective for treatment of HIV/AIDS, resulting in higher mean body weight, effective viral inhibition and a higher CD4 count. Immunological effectiveness of antiretroviral therapy positively correlates with HIV viral inhibition.read more
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Mortality, morbidity, and risk factors in China and its provinces, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
Maigeng Zhou,Haidong Wang,Xinying Zeng,Peng Yin,Jun Zhu,Wanqing Chen,Xiaohong Li,Lijun Wang,Limin Wang,Yunning Liu,Jiangmei Liu,Mei Zhang,Jinlei Qi,Shicheng Yu,Ashkan Afshin,Emmanuela Gakidou,Scott D Glenn,Varsha Sarah Krish,Molly K. Miller-Petrie,W Cliff Mountjoy-Venning,Erin C Mullany,Sofia Boston Redford,Hongyan Liu,Mohsen Naghavi,Simon I. Hay,Linhong Wang,Christopher J L Murray,Xiaofeng Liang +27 more
TL;DR: Stroke and ischaemic heart disease were the leading causes of death and DALYs at the national level in China in 2017, and China has made substantial progress in reducing the burden of many diseases and disabilities.
Journal ArticleDOI
Incomplete Recovery of CD4 Cell Count, CD4 Percentage, and CD4/CD8 Ratio in Patients With Human Immunodeficiency Virus Infection and Suppressed Viremia During Long-term Antiretroviral Therapy.
Yoshikazu Mutoh,Takeshi Nishijima,Yosuke Inaba,Noriko Tanaka,Yoshimi Kikuchi,Hiroyuki Gatanaga,Shinichi Oka +6 more
TL;DR: The results showed lack of normalization of CD4 count, CD4%, and CD4/CD8 ratio to the levels seen in healthy individuals even after long-term successful cART in patients with a suppressed VL.
Journal ArticleDOI
Shift in HIV/AIDS Epidemic in Southeastern China: A Longitudinal Study from 1987 to 2015
Yansheng Yan,Shouli Wu,Shouli Wu,Liang Chen,Pingping Yan,Yuefeng Qiu,Meirong Xie,Zhenghua Wang,Xun Lin +8 more
TL;DR: An increasing trend is still observed in the HIV/AIDS epidemics in Fujian Province, southeastern China, and effective control interventions targeting the shift in the epidemiological features of HIV/ AIDS should therefore be implemented to control the spread of the epidemic.
Journal ArticleDOI
Epidemiological profile and risk factors of HIV and HBV/HCV co-infection in Fujian Province, southeastern China
TL;DR: Hepatitis virus screening should be included in monitoring of HIV infection, and HIV and hepatitis virus co‐infection should be considered during the development of HIV antiretroviral therapy scheme.
Journal ArticleDOI
Rate of viral load change and adherence of HIV adult patients treated with Efavirenz or Nevirapine antiretroviral regimens at 24 and 48 weeks in Yaoundé, Cameroon: a longitudinal cohort study
Bih Hycenta Chendi,Marie Claire Okomo Assoumou,Graeme Brendon Jacobs,Elsie Laban Yekwa,Emilia Lyonga,Martha Tongo Mesembe,Agnes Eyoh,George Mondinde Ikomey +7 more
TL;DR: Evidence is added that the EFV regimen is the preferred ART combination for non-nucleoside reverse transcriptase inhibitors (NNRTIs) in patients treated with a combination of either Tenofovir, Lamivudine, or Efavirenz at 24 and 48 weeks.
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