Journal ArticleDOI
Effects of α- and β-adrenergic blocking agents on the biogenic amine stimulated (Na+K+) ATPase of rat cerebral cortical synaptosomal membrane
P.H. Wu,J.W. Phillis +1 more
TLDR
It is concluded that the stimulation of cerebral (Na + K + ) ATPase by biogenic amines could be a receptor-mediated process and it is possible that both α- and β-receptors activate a common mechanism.Abstract:
1. 1. Adrenergic agonists (adrenaline, noradrenaline, isoproterenol and phenylephrine) stimulate the activity of (Na + K + ) ATPase (EC 3.6.1.3) in rat cerebral cortical synaptosomal fractions. 2. 2. The potencies of the agonists on the stimulation of the enzyme arranged in descending order are adrenaline ⩾ noradrenaline > isoproterenol > phenylephrine. 3. 3. The response to noradrenaline can be antagonized by both α- and β-adrenergic blockers. 4. 4. We conclude that the stimulation of cerebral (Na + K + ) ATPase by biogenic amines could be a receptor-mediated process. 5. 5. The results also indicate that it is possible that both α- and β-receptors activate a common mechanism.read more
Citations
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Alpha-receptor-mediated facilitation of somatosensory cortical neuronal responses to excitatory synaptic inputs and iontophoretically applied acetylcholine.
TL;DR: The results suggest that endogenously released NE may facilitate excitatory synaptic transmission within the somatosensory cortex by activation of postsynaptic adrenoceptors with α characteristics.
Journal ArticleDOI
New concepts of molecular communication among neurons
TL;DR: A range of evidence suggests that neurons may use a variety of forms of molecular communication in addition to traditionally described synaptic transmission, including modes of communication distinct from classical synaptic transmission.
Journal ArticleDOI
Receptor independent stimulatory effect of noradrenaline on Na,K-ATPase in rat brain homogenate. Role of lipid peroxidation.
Vera Adam-Vizi,András Seregi +1 more
TL;DR: It is concluded that there is no correlation between the adrenoceptor agonist feature of noradrenaline and its stimulatory effect on Na,K-ATPase activity of rat brain homogenate and endogenous lipid peroxidation of considerable extent.
Journal ArticleDOI
The central noradrenergic transmission and the locus coeruleus: a review of the data, and their implications for neurotransmission and neuromodulation.
TL;DR: The locus coeruleus and neurotransmission, which is a neurotransmitter of the LC, and its effect on CNS signal processing, and interaction of NE with other neurohumors are studied.
Journal ArticleDOI
Catecholamines and the sodium pump in excitable cells.
J.W. Phillis,P.H. Wu +1 more
TL;DR: The role of calcium in catecholamine regulation of membrane Na +,K +-ATPase 6.2.1.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle.
TL;DR: A potent (Na,K)-ATPase inhibitor purified from "Sigma Grade* ATP" has been identified as vanadium using electron probe microanalysis and confirmed by microwave-induced emission spectroscopy and electron paramagnetic resonanceSpectroscopy.
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Studies on sodium-potassium-activated adenosine triphosphatase: I. Quantitative distribution in several tissues of the cat
TL;DR: The quantitative distribution of sodium-potassium-activated adenosine triphosphatase, which had been shown to play a role in active transport of sodium and potassium in erythrocytes, has been determined in 36 tissues of the cat and in human retina, ciliary body, and ery Throcytes.