Journal ArticleDOI
Effects of ageing on the content in sulfur-containing amino acids in rat brain
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TLDR
Changes in aspartic acid, glutamic acid, serine, glutamine, glycine and GABA concentrations with ageing were determined in the same brain structures and were in good agreement with those previously reported.Abstract:
Concentrations of the sulfur-containing amino acids methionine, homocysteic acid, cysteic acid and taurine were measured in brain structures of young and old Wistar rats in an attempt to establish a possible link between the increase in oxidative stress with ageing and changes in tissue levels of these amino acids. Contrary to data reported by others, in all brain structures of young and old rats homocysteic acid levels could not be quantified. Compared with young rats, in old animals taurine and methionine concentrations significantly decreased in striatum and cortex; decreased taurine levels were also found in nucleus accumbens and cerebellum and lower concentrations of methionine were found in midbrain, hippocampus and pons-medulla. Cysteic acid levels either did not change or significantly increased in cortex and hippocampus. These results are discussed taking into account the biosynthesis of sulfur-containing amino acids in rat brain and the decrease in glutathione in relation to oxidative stress with ageing. Changes in aspartic acid, glutamic acid, serine, glutamine, glycine and GABA concentrations with ageing were also determined in the same brain structures and were in good agreement with those previously reported (Strolin Benedetti et al., 1990 a, b).read more
Citations
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Oxidative stress induced in pathologies: the role of antioxidants.
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The use of various animal models in the study of stress and stress-related phenomena.
W. Sutanto,E.R. de Kloet +1 more
TL;DR: IfdWee6 efdWeeade\ S`[_S^ _aVW^e $^STadSfadk dSf%6 YW`Wf[U efdS],`Ifd wee& VWX[`WV Se S V[efgdTS`UW],`Za_WaefSe[e& iSe Xad_g^SfWV Tk ?
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Activation of GABAA receptors by taurine and muscimol blocks the neurotoxicity of β-amyloid in rat hippocampal and cortical neurons
TL;DR: The results suggest that activation of GABA(A) receptors protects neurons against Abeta toxicity in AD-affected regions of the mammalian brain and that taurine should be investigated as a novel therapeutic tool in the treatment of AD and of other neurological disorders in which excitotoxicity plays a relevant role.
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Taurine improves learning and retention in aged mice.
TL;DR: It is shown that chronic supplementation of taurine to aged mice significantly ameliorates the age-dependent decline in memory acquisition and retention and suggests a protective role of t aurine against the normal aging process.
References
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Journal ArticleDOI
Monoamine Oxidase and Disease: Prospects for Therapy with Reversible Inhibitors. Edited by K. F. Tipton, P. Dostert and M. Stroling Beneditti. Orlando, Florida: Academic Press, 1984. Pp. 694. £34.50.
Journal Article
Lipid peroxidation in mitochondrial membranes induced by enzymatic deamination of biogenic amines.
TL;DR: The highest stimulation of lipid peroxidation is observed in the samples containing both cadaverine and benzylamine, and the substrate of the monoamine oxidases of the type A, serotonin, causes an antioxidative effect under these conditions.
Book ChapterDOI
Effect of Selective Monoamine Oxidase Substrates and Inhibitors on Lipid Peroxidation and Their Possible Involvement in Affective Disorders
TL;DR: How the oxidative deamination of monoamines by monoamine oxidase (MAO) and its inhibition can affect lipid peroxidation (LPO) and the physiopathological processes in mental diseases related to this phenomenon is examined.
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[Etiology and pathogenesis of idiopathic Parkinsonism: a model].
Laplante M,Tran-Manh N +1 more