Journal ArticleDOI
Effects of ageing on the content in sulfur-containing amino acids in rat brain
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TLDR
Changes in aspartic acid, glutamic acid, serine, glutamine, glycine and GABA concentrations with ageing were determined in the same brain structures and were in good agreement with those previously reported.Abstract:
Concentrations of the sulfur-containing amino acids methionine, homocysteic acid, cysteic acid and taurine were measured in brain structures of young and old Wistar rats in an attempt to establish a possible link between the increase in oxidative stress with ageing and changes in tissue levels of these amino acids. Contrary to data reported by others, in all brain structures of young and old rats homocysteic acid levels could not be quantified. Compared with young rats, in old animals taurine and methionine concentrations significantly decreased in striatum and cortex; decreased taurine levels were also found in nucleus accumbens and cerebellum and lower concentrations of methionine were found in midbrain, hippocampus and pons-medulla. Cysteic acid levels either did not change or significantly increased in cortex and hippocampus. These results are discussed taking into account the biosynthesis of sulfur-containing amino acids in rat brain and the decrease in glutathione in relation to oxidative stress with ageing. Changes in aspartic acid, glutamic acid, serine, glutamine, glycine and GABA concentrations with ageing were also determined in the same brain structures and were in good agreement with those previously reported (Strolin Benedetti et al., 1990 a, b).read more
Citations
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Activation of GABAA receptors by taurine and muscimol blocks the neurotoxicity of β-amyloid in rat hippocampal and cortical neurons
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References
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Journal ArticleDOI
Release of neuroactive substances: homocysteic acid as an endogenous agonist of the NMDA receptor.
TL;DR: HCA is a transmitter candidate which acts predominantly on the NMDA receptor, and 35S-methionine can label the releasable pool of HCA, and thus appears as a precursor of H CA.
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Age‐Dependent Variations in Peroxide‐Utilizing Enzymes from Rat Brain Mitochondria and Cytoplasm
TL;DR: The location of peroxide‐utilizing enzymes has been studied in rat brain and a gradual but significant increase in glutathione peroxidase from the soluble fraction of free mitochondria was detected, discussed with regard to the reducing potential of the cell.
Journal Article
Pharmacology of the excitatory actions of sulphonic and sulphinic amino acids.
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Intestinal metabolism of tyramine by both forms of monoamine oxidase in the rat.
TL;DR: The two forms of monoamine oxidase (MAO) in rat intestine and brain homogenates were found to have different Km and Vmax values towards tyramine, and the significance of these results in relation to the "cheese effect" is discussed.
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Cysteine sulfinic acid in the central nervous system: uptake and release of cysteine sulfinic acid by a rat brain preparation.
TL;DR: Uptake and release of cysteine sulfinic acid by synaptosomal fractions (P2) and slices of rat cerebral cortex were investigated and Diazepam at concentrations of 10 and 100 μM markedly inhibited the stimulated release, but not the spontaneous release, by cortical slices.