Effects of e-cigarettes and vaping devices on cardiac and pulmonary physiology.
MuChun Tsai,Min Kwang Byun,Min Kwang Byun,Min Kwang Byun,John Shin,John Shin,Laura E. Crotty Alexander,Laura E. Crotty Alexander +7 more
TLDR
Data from both humans and animal models are consistent in demonstrating that vaping of e‐cigarettes causes health effects both similar to and disparate from those of cigarette smoking.Abstract:
E-cigarette aerosols are exceedingly different from conventional tobacco smoke, containing dozens of chemicals not found in cigarette smoke. It is highly likely that chronic use of e-cigarettes will induce pathological changes in both the heart and lungs. Here we review human and animal studies published to date and summarize the cardiopulmonary physiological changes caused by vaping. In terms of cardiac physiology, acute exposure to e-cigarette aerosols in human subjects led to increased blood pressure and heart rate, similar to traditional cigarettes. Chronic exposure to e-cigarette aerosols using animal models caused increased arterial stiffness, vascular endothelial changes, increased angiogenesis, cardiorenal fibrosis and increased atherosclerotic plaque formation. Pulmonary physiology is also affected by e-cigarette aerosol inhalation, with increased airway reactivity, airway obstruction, inflammation and emphysema. Research thus far demonstrates that the heart and lung undergo numerous changes in response to e-cigarette use, and disease development will depend on how those changes combine with both environmental and genetic factors. E-cigarettes have been advertised as a healthy alternative to cigarette smoking, and users are under the impression that vaping of e-cigarettes is harmless, but these claims that e-cigarettes are safer and healthier are not based on evidence. Data from both humans and animal models are consistent in demonstrating that vaping of e-cigarettes causes health effects both similar to and disparate from those of cigarette smoking. Further work is needed to define the long-term cardiopulmonary effects of e-cigarette use in humans.read more
Citations
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Electronic Cigarette Exposure Causes Vascular Endothelial Dysfunction Due to NADPH Oxidase Activation and eNOS Uncoupling.
Mohamed A. El-Mahdy,Mohamed G. Ewees,Mahmoud S Eid,Elsayed M Mahgoup,Sahar A. Khaleel,Jay L. Zweier +5 more
TL;DR: It is demonstrated that ECV exposure activates NADPH oxidase and uncouples eNOS, causing a vicious cycle of superoxide generation and vascular oxidant stress that triggers VED and hypertension with predisposition to other cardiovascular disease.
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Vaping and Lung Inflammation and Injury
TL;DR: In this article , the authors discuss the diverse spectrum of vaping exposures, epidemiological and clinical reports, and experimental findings to provide a better understanding of EVALI and the adverse health effects of chronic e-cigarette exposure.
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A Review of Toxicity Mechanism Studies of Electronic Cigarettes on Respiratory System
TL;DR: This review will summarize the toxicity mechanisms and signal pathways of conventional cigarettes and e-cigarette concerning the respiratory system to give researchers a better understanding and direction on the effects of e-cigarettes on the authors' health.
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Effects of mango and mint pod-based e-cigarette aerosol inhalation on inflammatory states of the brain, lung, heart, and colon in mice
TL;DR: The authors investigated the impact of inhaling aerosols produced from pod-based, flavored e-cigarettes (JUUL) aerosols three times daily for 3 months on inflammatory markers in the brain, lung, heart, and colon.
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Metals and air pollution
TL;DR: In this paper , a review of the relevant scientific literature providing insights on health-related effects caused by inhalation of particulate metals, and their potential causal pathways is presented, based on both the available epidemiologic and toxicological evidence.
References
More filters
Journal ArticleDOI
Circulating endothelial progenitor cells and cardiovascular outcomes.
Nikos Werner,Sonja Kosiol,Tobias Schiegl,Patrick Ahlers,Katrin Walenta,Andreas Link,Michael Böhm,Georg Nickenig +7 more
TL;DR: The association between baseline levels of endothelial progenitor cells and death from cardiovascular causes, the occurrence of a first major cardiovascular event, revascularization, hospitalization, anddeath from all causes were evaluated.
Journal ArticleDOI
Vitamin E Acetate in Bronchoalveolar-Lavage Fluid Associated with EVALI
Benjamin C. Blount,Mateusz P. Karwowski,Peter G. Shields,Maria Morel-Espinosa,Liza Valentin-Blasini,Michael G. Gardner,Martha E. Braselton,Christina R Brosius,Kevin T. Caron,David M. Chambers,Joseph Corstvet,Elizabeth A. Cowan,Víctor R. De Jesús,Paul Espinosa,Carolina Fernandez,Cory Holder,Zsuzsanna Kuklenyik,Jennifer D Kusovschi,Cody A. Newman,Gregory B. Reis,Jon Rees,Chris Reese,Lalith K. Silva,Tiffany H. Seyler,Min-Ae Song,Connie S. Sosnoff,Carleen R. Spitzer,Denise S. Tevis,Lanqing Wang,Cliff Watson,Mark D. Wewers,Baoyun Xia,Douglas T Heitkemper,Isaac Ghinai,Jennifer E. Layden,Peter A. Briss,Brian A. King,Lisa J. Delaney,Christopher M. Jones,Grant T. Baldwin,Anita Patel,Dana Meaney-Delman,Dale A. Rose,Vikram Krishnasamy,John R. Barr,Jerry D. Thomas,James L. Pirkle +46 more
TL;DR: Vitamin E acetate was associated with EVALI in a convenience sample of 51 patients in 16 states across the United States and was found in BAL fluid from the case patients or the comparator group.
Journal ArticleDOI
Short-term Pulmonary Effects of Using an Electronic Cigarette: Impact on Respiratory Flow Resistance, Impedance, and Exhaled Nitric Oxide
Constantine I. Vardavas,Nektarios Anagnostopoulos,Marios Kougias,Vassiliki Evangelopoulou,Gregory N. Connolly,Panagiotis Behrakis,Panagiotis Behrakis +6 more
TL;DR: In this paper, the authors found that using an e-cigarette for 5 min led to an immediate decrease in F ENO within the experimental group by 2.14 ppb (P 5.005) but not in the control group (P5.859), total respiratory impedance at 5 Hz in the experimental groups was found to also increase by 0.033 kPa/(L/s) (P,.001), and fl ow respiratory resistance at 5, 10, and 20 Hz also statistically increased.
Journal ArticleDOI
Acute impact of active and passive electronic cigarette smoking on serum cotinine and lung function
Andreas D. Flouris,Maria S. Chorti,Konstantina Poulianiti,Athanasios Z. Jamurtas,Konstantinos Kostikas,Manolis Tzatzarakis,A. Wallace Hayes,Aristidis Tsatsakis,Yiannis Koutedakis +8 more
TL;DR: Regarding short-term usage, the studied e-cigarettes generate smaller changes in lung function but similar nicotinergic impact to tobacco cigarettes, and future research should target the health effects of long-term e-cigarette usage, including the effects of nicotine dosage.
Journal ArticleDOI
Flavour chemicals in electronic cigarette fluids
TL;DR: The concentrations of some flavour chemicals in e-cigarette fluids are sufficiently high for inhalation exposure by vaping to be of toxicological concern, and regulatory limits should be contemplated.
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