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Effects of friction on the unconfined compressive response of articular cartilage: a finite element analysis.

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TLDR
These studies show that interfacial friction plays a major role in the unconfined compression response of articular cartilage specimens with small thickness to diameter ratios.
Abstract
A finite element analysis is used to study a previously unresolved issue of the effects of platen-specimen friction on the response of the unconfined compression test; effects of platen permeability are also determined. The finite element formulation is based on the linear KLM biphasic model for articular cartilage and other hydrated soft tissues. A Galerkin weighted residual method is applied to both the solid phase and the fluid phase, and the continuity equation for the intrinsically incompressible binary mixture is introduced via a penalty method. The solid phase displacements and fluid phase velocities are interpolated for each element in terms of unknown nodal values, producing a system of first order differential equations which are solved using a standard numerical finite difference technique. An axisymmetric element of quadrilateral cross-section is developed and applied to the mechanical test problem of a cylindrical specimen of soft tissue in unconfined compression. These studies show that interfacial friction plays a major role in the unconfined compression response of articular cartilage specimens with small thickness to diameter ratios.

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Citations
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Journal ArticleDOI

Chondrocyte deformation and local tissue strain in articular cartilage: a confocal microscopy study.

TL;DR: The hypothesis that deformation of chondrocytes or a change in their volume may occur during in vivo joint loading and may have a role in the mechanical signal transduction pathway of articular cartilage is supported.
Journal ArticleDOI

The mechanical environment of the chondrocyte: a biphasic finite element model of cell–matrix interactions in articular cartilage

TL;DR: These findings suggest that even under simple compressive loading conditions, chondrocytes are subjected to a complex local mechanical environment consisting of tension, compression, shear, and fluid pressure.
Journal ArticleDOI

Effects of Cyclic Compressive Loading on Chondrogenesis of Rabbit Bone-Marrow Derived Mesenchymal Stem Cells

TL;DR: It is suggested that cyclic compressive loading can promote the chondrogenesis of rabbit BM‐MSCs by inducing the synthesis of TGF‐β1, which can stimulate the BM‐ MSCs to differentiate into chondrocytes.
Journal ArticleDOI

Mechano-electrochemical properties of articular cartilage: their inhomogeneities and anisotropies.

TL;DR: In this paper, the recent advances in cartilage biomechanics and electromechanics are reviewed and summarized, focusing on the new experimental and theoretical findings of cartilage mechanics.

MECHANO-ELECTROCHEMICAL PROPERTIES OF ARTICULAR CARTILAGE: Their Inhomogeneities

Van C. Mow, +1 more
TL;DR: The charged nature and depth-dependent inhomogeneity in mechano-electrochemical properties of articular cartilage are examined, and their importance in the normal and/or pathological structure-function relationships with cartilage is discussed, along with their pathophysiological implications.
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