Journal ArticleDOI
Effects of friction on the unconfined compressive response of articular cartilage: a finite element analysis.
Reads0
Chats0
TLDR
These studies show that interfacial friction plays a major role in the unconfined compression response of articular cartilage specimens with small thickness to diameter ratios.Abstract:
A finite element analysis is used to study a previously unresolved issue of the effects of platen-specimen friction on the response of the unconfined compression test; effects of platen permeability are also determined. The finite element formulation is based on the linear KLM biphasic model for articular cartilage and other hydrated soft tissues. A Galerkin weighted residual method is applied to both the solid phase and the fluid phase, and the continuity equation for the intrinsically incompressible binary mixture is introduced via a penalty method. The solid phase displacements and fluid phase velocities are interpolated for each element in terms of unknown nodal values, producing a system of first order differential equations which are solved using a standard numerical finite difference technique. An axisymmetric element of quadrilateral cross-section is developed and applied to the mechanical test problem of a cylindrical specimen of soft tissue in unconfined compression. These studies show that interfacial friction plays a major role in the unconfined compression response of articular cartilage specimens with small thickness to diameter ratios.read more
Citations
More filters
Journal ArticleDOI
Chondrocyte deformation and local tissue strain in articular cartilage: a confocal microscopy study.
TL;DR: The hypothesis that deformation of chondrocytes or a change in their volume may occur during in vivo joint loading and may have a role in the mechanical signal transduction pathway of articular cartilage is supported.
Journal ArticleDOI
The mechanical environment of the chondrocyte: a biphasic finite element model of cell–matrix interactions in articular cartilage
Farshid Guilak,Van C. Mow +1 more
TL;DR: These findings suggest that even under simple compressive loading conditions, chondrocytes are subjected to a complex local mechanical environment consisting of tension, compression, shear, and fluid pressure.
Journal ArticleDOI
Effects of Cyclic Compressive Loading on Chondrogenesis of Rabbit Bone-Marrow Derived Mesenchymal Stem Cells
C-Y Charles Huang,C-Y Charles Huang,Kristen L. Hagar,Lauren E. Frost,Yubo Sun,Herman S. Cheung,Herman S. Cheung +6 more
TL;DR: It is suggested that cyclic compressive loading can promote the chondrogenesis of rabbit BM‐MSCs by inducing the synthesis of TGF‐β1, which can stimulate the BM‐ MSCs to differentiate into chondrocytes.
Journal ArticleDOI
Mechano-electrochemical properties of articular cartilage: their inhomogeneities and anisotropies.
Van C. Mow,X. Edward Guo +1 more
TL;DR: In this paper, the recent advances in cartilage biomechanics and electromechanics are reviewed and summarized, focusing on the new experimental and theoretical findings of cartilage mechanics.
MECHANO-ELECTROCHEMICAL PROPERTIES OF ARTICULAR CARTILAGE: Their Inhomogeneities
Van C. Mow,X. Edward Guo +1 more
TL;DR: The charged nature and depth-dependent inhomogeneity in mechano-electrochemical properties of articular cartilage are examined, and their importance in the normal and/or pathological structure-function relationships with cartilage is discussed, along with their pathophysiological implications.
Related Papers (5)
An analysis of the unconfined compression of articular-cartilage
A triphasic theory for the swelling and deformation behaviors of articular cartilage.
W. M. Lai,J. S. Hou,Van C. Mow +2 more