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Effects of Hyaluronidase Administration on Myocardial Ischemic Injury in Acute Infarction

Peter R. Maroko, +4 more
- 12 Mar 2020 - 
TLDR
It is shown that hyaluronidase can accelerate the reduction of myocardial ischemic injury in patients with acuteMyocardial infarction.
Abstract: 
The effect of hyaluronidase on myocardial ischemic injury was examined in 13 patients with acute myocardial infarction, and the results were compared with 11 patients who did not receive h...

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Citations
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Journal ArticleDOI

Hyaluronan as an Immune Regulator in Human Diseases

Dianhua Jiang, +2 more
- 01 Jan 2011 - 
TL;DR: This review focuses on the role of hyaluronan as an immune regulator in human diseases through regulating inflammatory cell recruitment, release of inflammatory cytokines, and cell migration.
Journal ArticleDOI

Reduction by Cobra Venom Factor of Myocardial Necrosis after Coronary Artery Occlusion

Peter R. Maroko, +6 more
- 01 Mar 1978 - 
TL;DR: It is concluded that cobra venom factor, by reducing the amount of C3 and C5 substrate available for chemotactic factor generation, or other as yet undefined mechanisms, protects the ischemic myocardium from undergoing necrosis, as judged by histology and local CPK activity.
Journal ArticleDOI

TQ-ST segment mapping: critical review and analysis of current concepts.

Roger P. Holland, +1 more
- 01 Jul 1977 - 
TL;DR: Further study of the complex behavior of the TQ-ST segment deflection, particularly in the presence of pharmacologic intervention, is necessary before mapping techniques can be used reliably in clinical studies designed to quantitate and modify ischemic damage.
Journal ArticleDOI

Effects of dobutamine in patients with acute myocardial infarction.

Thomas A. Gillespie, +3 more
- 01 Jan 1977 - 
TL;DR: Administration of dobutamine in doses sufficient to improve ventricular performance after myocardial infarction does not exacerbate my Cardioselective injury or ventricular dysrhythmia, and the ratio of observed to predicted infarct size, the frequency of independently detected reinfarction or extension ofinfarction and the Frequency of premature ventricular complexes were similar in control and treated patients.
Journal ArticleDOI

Long-Term Preservation of Ischemic Myocardium after Experimental Coronary Artery Occlusion

Derek Maclean, +3 more
- 01 Mar 1978 - 
TL;DR: The left coronary artery was occluded in 880 rats and the amount of normal myocardium preserved at 21 days postocclusion was significantly increased, and although ventricular rupture did not occur, the intervention caused distension of the left ventricle as a result of stretching of the infarcted tissue during scar formation.
References
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Journal ArticleDOI

Factors Influencing Infarct Size Following Experimental Coronary Artery Occlusions

Peter R. Maroko, +6 more
- 01 Jan 1971 - 
TL;DR: It is concluded that the hemodynamic status and neurohumoral background at the time of occlusion and for up to 3 hr thereafter can alter the extent and severity of myocardial ischemic injury andMyocardial necrosis.
Journal ArticleDOI

Hyaluronan as an Immune Regulator in Human Diseases

Dianhua Jiang, +2 more
- 01 Jan 2011 - 
TL;DR: This review focuses on the role of hyaluronan as an immune regulator in human diseases through regulating inflammatory cell recruitment, release of inflammatory cytokines, and cell migration.
Journal ArticleDOI

Precordial S-T segment elevation mapping: An atraumatic method for assessing alterations in the extent of myocardial ischemic injury

Peter R. Maroko, +5 more
- 01 Feb 1972 - 
TL;DR: Precordial mapping, both in dogs and patients, shows changes parallel to those measured by the epicardial technique and should provide a useful clinical tool for determining acute changes in the extent of ischemic injury.
Journal ArticleDOI

Modification of myocardial infarction size after coronary occlusion.

Peter R. Maroko, +1 more
- 01 Nov 1973 - 
TL;DR: Several pharmacologic and hemodynamic interventions were found to alter acute ischemic injury of the myocardium and subsequent necrosis after coronary occlusion and reduction in myocardial thickness was found.
Journal ArticleDOI

Reduction by Cobra Venom Factor of Myocardial Necrosis after Coronary Artery Occlusion

Peter R. Maroko, +6 more
- 01 Mar 1978 - 
TL;DR: It is concluded that cobra venom factor, by reducing the amount of C3 and C5 substrate available for chemotactic factor generation, or other as yet undefined mechanisms, protects the ischemic myocardium from undergoing necrosis, as judged by histology and local CPK activity.