Effects of Time and Duration of Progesterone Administration on Mammary Tumours Induced by 7,12-Dimethylbenz(a)Anthracene in Sprague-Dawley Rats
TLDR
In contrast, when progesterone injections were begun 2 days after feeding DMBA, there was a trend towards enhancement of tumour yield, and continuous hormone administration appeared more effective than shorter treatment regimens.Abstract:
Effects of Time and Duration of Progesterone Administration on Mammary Tumours Induced by 7,12-Dimethylbenz(a)Anthracene in Sprague-Dawley Ratsread more
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Ovary-intact, but not ovariectomized female ACI rats treated with 17beta-estradiol rapidly develop mammary carcinoma.
TL;DR: The data indicate that the ovary modulates estrogen-mediated mammary carcinogenesis in this rat strain, and that estrogen-induced hyperprolactinemia is not the sole factor leading to development of mammary cancers in the E2-treated ACI rat.
Journal ArticleDOI
The MPA mouse breast cancer model: evidence for a role of progesterone receptors in breast cancer.
Claudia Lanari,Caroline A. Lamb,Victoria Teresa Fabris,Luisa A. Helguero,Rocío Soldati,Maria Cecilia Bottino,Sebastián Giulianelli,Juan P. Cerliani,Victoria Wargon,Alfredo A. Molinolo +9 more
TL;DR: A model of breast cancer in which the administration of medroxyprogesterone acetate to BALB/c female mice induces mammary ductal carcinomas with a mean latency of 52 weeks and an incidence of about 80%, highlighting the role of PR as a trigger of key signaling pathways mediating tumor growth.
Journal ArticleDOI
Progestin effects on growth in the human breast cancer cell line T-47D—Possible therapeutic implications
TL;DR: The results raise the possibility that estrogen receptor and progesterone receptor-rich breast cancer patients might benefit more from a combination of anti-progestin andAnti-estrogen therapy than from anti-estrogens alone.
Journal Article
Reversal of the antitumor effects of tamoxifen by progesterone in the 7,12-dimethylbenzanthracene-induced rat mammary carcinoma model.
TL;DR: It is demonstrated that progesterone can reverse the tumoristatic action of tamoxifen in the 7,12-dimethylbenzanthracene-induced tumor model and that this may be via a progester one receptor-mediated mechanism.
Journal ArticleDOI
Multiple actions of synthetic 'progestins' on the growth of ZR-75-1 human breast cancer cells: an in vitro model for the simultaneous assay of androgen, progestin, estrogen, and glucocorticoid agonistic and antagonistic activities of steroids.
TL;DR: The present data indicate that ‘progestin’ is an inappropriate name for MPA, NRE, NRG, MGA, CMA, and CPA, which all possess other and sometimes more potent steroidal activites than those related to interaction with the progesterone receptor.
References
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The uptake of progesterone by the uterus of the pregnant rat in vivo and its relationship to cytoplasmic progesterone-binding protein.
I J Davies,Kenneth J. Ryan +1 more
TL;DR: The uptake of progesterone-l,2-3H by the uterus of the pregnant rat following sc injection of the radiolabeled hormone was studied and the 3H-progesterone concentration in the uterus exceeded that in plasma while the concentration in thigh muscle was lower than plasma.
Journal ArticleDOI
Three types of mammary tumour induced in rats by feeding with dmba.
TL;DR: Images courtesy of AFP, EPA, Getty Images and Reuters.