Journal ArticleDOI
Efficacy and Safety of Tadalafil for the Treatment of Erectile Dysfunction: Results of Integrated Analyses
Gerald Brock,Chris McMahon,K.K. Chen,Timothy Costigan,Wei Shen,Vish Watkins,Greg Anglin,Steve Whitaker +7 more
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TLDR
Tadalafil was consistently efficacious across disease severities and etiologies, as well as in patients of all ages, and well tolerated in this patient population.About:
This article is published in The Journal of Urology.The article was published on 2002-10-01. It has received 527 citations till now. The article focuses on the topics: Tadalafil & Phosphodiesterase 5 inhibitor.read more
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Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation.
Konstantinos Hatzimouratidis,Edouard Amar,Ian Eardley,François Giuliano,Dimitrios Hatzichristou,Francesco Montorsi,Yoram Vardi,Eric Wespes +7 more
TL;DR: The updated version of 2009 European Association of Urology guidelines on ED and PE are presented to present, summarising the present information onED and PE.
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Physiology of Penile Erection and Pathophysiology of Erectile Dysfunction
Robert C. Dean,Tom F. Lue +1 more
TL;DR: The molecular and clinical under-standing of erectile function continues to gain ground at a particularly fast rate and the understanding of the nitric oxide pathway has aided not only in the molecular understand of the tumescence but also greatly in the therapy of erectILE dysfunction.
Journal ArticleDOI
Erectile Dysfunction: AUA Guideline.
Arthur L. Burnett,Ajay Nehra,Rodney H. Breau,Daniel J. Culkin,Martha M. Faraday,Lawrence S. Hakim,Joel J. Heidelbaugh,Mohit Khera,Kevin T. McVary,Martin Miner,Christian J. Nelson,Hossein Sadeghi-Nejad,Allen D. Seftel,Alan W. Shindel +13 more
TL;DR: This document is designed to be used in conjunction with the associated treatment algorithm, and all patients should be informed of all treatment modalities that are not contraindicated, regardless of invasiveness or irreversibility, as potential first‐line treatments.
Journal ArticleDOI
Differences in hemodynamic and oxygenation responses to three different phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension: a randomized prospective study.
Hossein Ardeschir Ghofrani,Robert Voswinckel,Frank Reichenberger,Horst Olschewski,Peter Haredza,Burcu Karadaş,Ralph T. Schermuly,Norbert Weissmann,Werner Seeger,Friedrich Grimminger +9 more
TL;DR: In PAH patients, the three PDE5 inhibitors differ markedly in their kinetics of pulmonary vasorelaxation (most rapid effect by vardenafil), their selectivity for the pulmonary circulation, and their impact on arterial oxygenation (improvement with sildenafil only).
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Minimal clinically important differences in the erectile function domain of the International Index of Erectile Function scale.
TL;DR: This analysis provides, for the first time, anchor-based estimates of MCIDs in the EF domain score of the IIEF, and shows how the contextualization of treatment-related changes in terms of clinically relevant improvement is essential to understanding treatment efficacy, to interpreting results across studies, and to managing patients effectively.
References
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The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction
TL;DR: The IIEF addresses the relevant domains of male sexual function, is psychometrically sound, and has been linguistically validated in 10 languages and demonstrates the sensitivity and specificity for detecting treatment-related changes in patients with erectile dysfunction.
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Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study.
TL;DR: It is concluded that impotence is a major health concern in light of the high prevalence, is strongly associated with age, has multiple determinants, including some risk factors for vascular disease, and may be due partly to modifiable para-aging phenomena.
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Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group.
Irwin Goldstein,Tom F. Lue,Harin Padma-Nathan,Raymond C. Rosen,William D. Steers,Pierre A. Wicker +5 more
TL;DR: Oral sildenafil is an effective, well-tolerated treatment for men with erectile dysfunction and is associated with improved erectile function in the dose-response study.
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Diagnostic evaluation of the erectile function domain of the International Index of Erectile Function.
TL;DR: The EF domain possesses favorable statistical properties as a diagnostic tool, not only in distinguishing between men with and without erectile dysfunction, but also in classifying levels of ED severity.
Journal ArticleDOI
Oral Sildenafil in the Treatment of Erectile Dysfunction
Irwin Goldstein,Tom F. Lue,Harin Padma-Nathan,Raymond C. Rosen,William D. Steers,Pierre A. Wicker +5 more
TL;DR: In this paper, the authors evaluated the efficacy and safety of sildenafil, administered as needed in two sequential double-blind studies of men with erectile dysfunction of organic, psychogenic, or mixed causes.