Elevation of γ-Aminobutyric Acid in Brain: Selective Inhibition of γ-Aminobutyric-α-ketoglutaric Acid Transaminase
Claude F. Baxter,Eugene Roberts +1 more
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This article is published in Journal of Biological Chemistry.The article was published on 1961-12-01 and is currently open access. It has received 205 citations till now. The article focuses on the topics: Aminobutyric acid & Ketoglutaric Acid.read more
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Book ChapterDOI
Epilepsy and gamma-aminobutyric acid-mediated inhibition.
TL;DR: This chapter discusses epilepsy and γ-aminobutyric acid (GABA) mediated inhibition and the principal sites where GABA produces hyperpolarization of the neuronal membrane, which resembles the physiologically induced inhibitory postsynaptic potential (IPSP).
Journal ArticleDOI
Effects of DI-n-propylacetate, and anticonvulsive compound, on GABA metabolism.
TL;DR: The effects on GABA metabolism of an anticonvulsant drug, di‐n‐propylacetate (DPA), were studied and it was found that intraperitoneally DPA increases the brain GABA content and does not change its biosynthesis from glutamic acid.
Journal ArticleDOI
Biochemical-physiological correlations in studies of the gamma-aminobutyric acid system.
Eugene Roberts,Kinya Kuriyama +1 more
Journal ArticleDOI
Some properties of L-glutamic decarboxylase in mouse brain.
Eugene Roberts,Daisy G. Simonsen +1 more
TL;DR: Experiments with hydroxylamine and α-hydrazinophenylacetic acid showed that the rate of loss of enzymic activity during preincubation of the brain homogenate with these agents was less than in absence of inhibitor, a finding consistent with the interpretation that the major mode of inhibition by carbonyltrapping agents is by combination with the holoenzyme.
Journal ArticleDOI
Benzodiazepines: potentiation of a GABA inhibitory response in the dorsal raphe nucleus.
TL;DR: Although the BZs did not alter the spontaneous firing rate of the DR, both the systemic and iontophoretic administration of these drugs were found to potentiate the inhibitory response produced by GABA, suggesting that this potentiation is mediated postsynaptically.
References
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Journal ArticleDOI
Qualitative analysis of proteins: a partition chromatographic method using paper.
Journal ArticleDOI
The distribution of glutamic decarboxylase in the nervous system of the rhesus monkey.
R. Wayne Albers,Roscoe O. Brady +1 more
Journal ArticleDOI
THE FLUORIMETRIC MEASUREMENT OF GLUTAMIC DECARBOXYLASE and ITS DISTRIBUTION IN BRAIN
TL;DR: It has been found that certain amino acids and indole derivatives, when allowed to react with ninhydrin at an alkaline pHS, form highly fluorescent products that can be measured in as little as 3 ,ug dry weight of brain tissue.
Journal ArticleDOI
Studies on the GABA pathway. I. The inhibition of gamma-aminobutyric acid-alpha-ketoglutaric acid transaminase in vitro and in vivo by U-7524 (amino-oxyacetic acid).
TL;DR: Amino-oxyacetic acid has been found to be a potent inhibitor of the enzyme γ-aminobutyric acid-α-ketoglutaric acid transaminase derived both from E. coli and mammalian brain.
Journal ArticleDOI
Soluble γ-Aminobutyric-Glutamic Transaminase from Pseudomonas fluorescens
TL;DR: The present report summarizes the data on the purification and properties of y-aminobutyric-glutamic transaminase and presents a kinetic analysis of the reaction which it catalyzes and describes the substrate specific, succinic semialdehyde dehydrogenase described by Black (10) .