Some properties of L-glutamic decarboxylase in mouse brain.

doi:10.1016/0006-2952(63)90177-1

Journal ArticleDOI

Some properties of L-glutamic decarboxylase in mouse brain.

Eugene Roberts, +1 more

- 01 Feb 1963 -

Biochemical Pharmacology

- Vol. 12, Iss: 2, pp 113-134

Chats0

TLDR

Experiments with hydroxylamine and α-hydrazinophenylacetic acid showed that the rate of loss of enzymic activity during preincubation of the brain homogenate with these agents was less than in absence of inhibitor, a finding consistent with the interpretation that the major mode of inhibition by carbonyltrapping agents is by combination with the holoenzyme.

About:

This article is published in Biochemical Pharmacology.The article was published on 1963-02-01. It has received 328 citations till now. The article focuses on the topics: Glutamate decarboxylase activity & Non-competitive inhibition.

Citations

PDF

Open Access

More filters

Journal ArticleDOI

Selective loss of central cholinergic neurons in alzheimer's disease

Peter Davies, +1 more

- 25 Dec 1976 -

The Lancet

Journal ArticleDOI

Neurotransmitter-related enzymes in senile dementia of the Alzheimer type.

Peter Davies

- 03 Aug 1979 -

Brain Research

TL;DR: Large, widespread reductions in the activities of ChAT and AChE were found in tissues from SDAT cases, while GAD activities were reduced in 3 of the 20 regions investigated.

...read moreread less

Journal ArticleDOI

Kainic acid induced seizures: Neurochemical and histopathological changes

Günther Sperk, +5 more

- 01 Dec 1983 -

Neuroscience

TL;DR: The most pronounced behavioural changes were strong immobility, increased incidence of "wet dog shakes", and long-lasting generalized tonic-clonic convulsions, suggesting a strongly increased firing rate of aminergic neurones during the period of generalized seizures.

...read moreread less

Book ChapterDOI

Epilepsy and gamma-aminobutyric acid-mediated inhibition.

Meldrum Bs

- 01 Jan 1975 -

International Review of Neurobiology

TL;DR: This chapter discusses epilepsy and γ-aminobutyric acid (GABA) mediated inhibition and the principal sites where GABA produces hyperpolarization of the neuronal membrane, which resembles the physiologically induced inhibitory postsynaptic potential (IPSP).

...read moreread less

Book ChapterDOI

Transport and metabolism of glutamate and GABA in neurons are glial cells.

Arne Schousboe

- 01 Jan 1981 -

International Review of Neurobiology

TL;DR: It is undoubtedly correct that these amino acids can be taken up into presynaptic nerve endings through high-affinity transport processes and it is even possible to distinguish between these transport mechanisms employing inhibitors that have been shown to be selective for the transport carriers.

...read moreread less