Journal ArticleDOI
Embryonic vertebrate central nervous system: Revised terminology
Jay B. Angevine,David Bodian,Alfred J. Coulombre,Mac V. Edds,Viktor Hamburger,Marcus Jacobson,Katherine M. Lyser,Martin C. Prestige,Richard L. Sidman,Silvio Varon,Paul Weiss +10 more
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TLDR
A revision is proposed in which the four fundamental zones are termed the ventricular, subventricular, intermediate, and marginal zones, each defined according to the form, behavior, and fate of its constituent cells.Abstract:
The layers and cells of the early developing central nervous system lack direct counterparts in the adult and must be designated by a special terminology. The inconsistent and inaccurate language now in use leads to misunderstanding and a revision is proposed in which the four fundamental zones are termed the ventricular, subventricular, intermediate, and marginal zones. Each is defined according to the form, behavior, and fate of its constituent cells. All neurons and macroglia of the central nervous system can be derived from these developmental zones.read more
Citations
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Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.
Deborah C. Rice,Stan Barone +1 more
TL;DR: Of critical concern is the possibility that developmental exposure to neurotoxicants may result in an acceleration of age-related decline in function, and the fact that developmental neurotoxicity that results in small effects can have a profound societal impact when amortized across the entire population and across the life span of humans.
Journal ArticleDOI
The glial nature of embryonic and adult neural stem cells
TL;DR: The timing in development and location of NSCs, a property tightly linked to their neuroepithelial origin, appear to be the key determinants of the types of neurons generated.
Journal ArticleDOI
Mode of cell migration to the superficial layers of fetal monkey neocortex.
TL;DR: Golgi and electronmicroscopic methods were used to define the shapes and intercellular relationships of cells migrating from their sites of origin near the ventricular surface across the intermediate zone to the superficial neocortical layers of the parietooccipital region in the brains of 75‐ to 97‐day monkey fetuses.
Journal ArticleDOI
Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases
TL;DR: It is shown here that neurons are generated in two proliferative zones by distinct patterns of division, and newborn neurons do not migrate directly to the cortex; instead, most exhibit four distinct phases of migration, including a phase of retrograde movement toward the ventricle before migration to the cortical plate.
Journal ArticleDOI
The blood-brain barrier: an overview: structure, regulation, and clinical implications.
Praveen Ballabh,Alex Braun +1 more
TL;DR: The pathogenesis of increased BBB permeability in hypoxia-ischemia and inflammatory mechanisms involving the BBB in septic encephalopathy, HIV-induced dementia, multiple sclerosis, and Alzheimer disease are described.
References
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Mitosis in the neural tube
TL;DR: The writer's interest in the mitoses of the neural tube arose as a result of finding, in the neural plate and early neural tube stages of the chick, appearances that seemed not in harmony with the usual accounts.
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The subependymal layer of the mouse brain and its cell production as shown by radioautography after thymidine‐H3 injection
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Cell proliferation and migration in the primitive ependymal zone; An autoradiographic study of histogenesis in the nervous system
TL;DR: The data show that the cells of the primitive ependymal layer behave synchronously, and that the sites of DNA synthesis and mitosis are different, and the views of Schaper and Sauer are confirmed.
Journal ArticleDOI
An electron microscopic analysis of gliogenesis in rat optic nerves.
TL;DR: Transitional forms between the cell varieties present during development suggest a direct lineage from the neuroectodermal matrix cells lining the lumen of the optic stalk to all neuroglial cell types.
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