Endothelial cell-matrix interactions: in vitro models of angiogenesis.
Joseph A. Madri,Bruce M. Pratt +1 more
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In this review, data, accrued from in vitro systems, that support the hypothesis that the subendothehal matrix is a determining factor in modulating the behavior of the overlying endothelial cell population are discussed.Abstract:
Introduction The endothelium is composed of a number of heterogeneous cell populations from a variety of vascular beds. Endothelial cells from these diverse beds share some common structures and functions but also exhibit a wide range of diversity in their morphological appearance, function, and response to injury (2,6,22). One factor that is thought to play key, if not pivotal, roles in the modulation of endothelial cell behavior is the extracellular matrix (21,24,2 5). A great deal of morphological evidence (at light and electron microscopic levels) supports the notion that the nature of the subendothelial matrix underlying endothelial cells varies depending on such criteria as size and type of artery and the particular microvascular bed examined (15,36,37). These differences in matrix, although still incompletely documented biochemically and immunochemicaliy, have led to the hypothesis that the subendothehal matrix is a determining factor in modulating the behavior of the overlying endothelial cell population. In this review we will discuss data, accrued from in vitro systems, that support this notion. Both large vessel (arterial) and microvascular (capillary) endothelial cell culture systems will be discussed. Because of the limited length of this review, its content is selective and will focus on the data of only several of the many laboratories actively working in this area.read more
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Role of transforming growth factor-beta in the development of the mouse embryo.
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