Journal ArticleDOI
Entry of EGF into brain is rapid and saturable
Weihong Pan,Abba J. Kastin +1 more
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TLDR
It is shown that 125I-EGF crosses the BBB rapidly, with an influx rate of about 2 microl/g x min, much faster than that for neurotrophins, cytokines, and most other bioactive peptides tested.About:
This article is published in Peptides.The article was published on 1999-09-01. It has received 93 citations till now. The article focuses on the topics: Epidermal growth factor & Neurotrophin.read more
Citations
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Journal ArticleDOI
Structure and function of the blood–brain barrier
TL;DR: The structure and function of the BBB is summarised, the physical barrier formed by the endothelial tight junctions, and the transport barrier resulting from membrane transporters and vesicular mechanisms are described.
Journal ArticleDOI
The source of cerebral insulin.
TL;DR: BBB transport of insulin provides a mechanism for peripheral insulin to act within the CNS as a regulatory peptide, with the transport rate of insulin being altered during development and by fasting, obesity, hibernation, diabetes mellitus and Alzheimer's disease.
Journal ArticleDOI
Delivery of neurotrophic factors to the central nervous system: pharmacokinetic considerations.
TL;DR: The development of targeted drug delivery strategies for neurotrophic factors will probably determine their clinical effectiveness for CNS conditions, while limiting systemic exposure and distribution to peripheral sites of action will lessen unwanted pleiotropic effects and toxicity.
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Blood-brain barrier transport of cytokines: a mechanism for neuropathology.
TL;DR: Some of the major principles and concepts relating to cytokine transport and BBB function which have emerged as important to neuroimmunology and neuropathology are addressed.
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The blood-brain barrier and immune function and dysfunction.
TL;DR: Four aspects of BBB-neuroimmune interactions are considered: BBB disruption as mediated by LPS and cytokines, cytokine transport across theBBB, immune cell trafficking, and effects of lipopolysaccharide (LPS) on various functions of the BBB.
References
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Journal ArticleDOI
Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data:
TL;DR: A theoretical model of blood–brain exchange is developed and a procedure is derived that can be used for graphing multiple-time tissue uptake data and determining whether a unidirectional transfer process was dominant during part or all of the experimental period.
Journal ArticleDOI
Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born Animal
TL;DR: The isolation of the factor responsible for the earlier development of the incisors and eyelids is reported here, a heat-stable, nondialysable, antigenic protein, whose most distinctive chemical characteristic is the absence of phenylalanine and lysine.
Journal ArticleDOI
Receptors for epidermal growth factor and other polypeptide mitogens.
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Murine tumor necrosis factor alpha is transported from blood to brain in the mouse.
TL;DR: It is shown that murine tumor necrosis factor alpha labeled with 125I (I-mTNF alpha) crosses the blood-brain barrier (BBB) after i.v. injection, suggesting that TNF alpha is sequestered by the brain.
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Transport of α-Aminoisobutyric Acid across Brain Capillary and Cellular Membranes
TL;DR: These studies indicated that the transport of AIB into brain cells was approximately 110 to 265 times greater than that across normal brain capillaries per unit mass of brain tissue, and that the BBB limits blood-to-brain cell transport of this amino acid.
Related Papers (5)
TNFα Transport across the Blood–Brain Barrier Is Abolished in Receptor Knockout Mice
Weihong Pan,Abba J. Kastin +1 more