Journal ArticleDOI
Murine tumor necrosis factor alpha is transported from blood to brain in the mouse.
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TLDR
It is shown that murine tumor necrosis factor alpha labeled with 125I (I-mTNF alpha) crosses the blood-brain barrier (BBB) after i.v. injection, suggesting that TNF alpha is sequestered by the brain.About:
This article is published in Journal of Neuroimmunology.The article was published on 1993-09-01. It has received 555 citations till now. The article focuses on the topics: Alpha (ethology) & Blood–brain barrier.read more
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Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action
TL;DR: Findings are reviewed that have documented which cytokines have been shown to influence hormone secretion from the HPA axis, determined under what physiological/pathophysiological circumstances endogenous cytokines regulate HPAaxis activity, established the possible sites of cytokine action on HPA Axis hormone secretion, and identified the potential neuroanatomic and pharmacological mechanisms by which cytokine signal the neuroendocrine hypothalamus.
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Leptin enters the brain by a saturable system independent of insulin.
William A. Banks,Abba J. Kastin,Abba J. Kastin,Weitao Huang,Weitao Huang,Jonathan B. Jaspan,Jonathan B. Jaspan,Lawrence M. Maness,Lawrence M. Maness +8 more
TL;DR: Results show that leptin is transported intact from blood to brain by a saturable system and inhibited the influx of 125I-leptin in a dose-dependent manner whereas unlabeled tyrosine and insulin, which have saturable transport systems, were without effect.
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Transport of brain-derived neurotrophic factor across the blood-brain barrier
TL;DR: It is concluded that intact BDNF in the peripheral circulation crosses the blood-brain barrier by a high-capacity, saturable transport system.
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Inflammation as a central mechanism in Alzheimer's disease
Jefferson W. Kinney,Shane M. Bemiller,Andrew S. Murtishaw,Amanda M. Leisgang,Arnold Salazar,Bruce T. Lamb +5 more
TL;DR: An overview of inflammation in AD is provided and a detailed coverage of a number of microglia‐related signaling mechanisms that have been implicated in AD are reviewed.
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Maternal intrauterine infection, cytokines, and brain damage in the preterm newborn
Olaf Dammann,Alan Leviton +1 more
TL;DR: Unifying models postulate how proinflammatory cytokines might lead to IVH and neonatal white matter damage during prenatal maternal infection and intervene to prevent later disability in those born near the end of the second trimester.
References
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An endotoxin-induced serum factor that causes necrosis of tumors
TL;DR: It is proposed that TNF mediates endotoxin-induced tumor necrosis, and that it may be responsible for the suppression of transformed cells by activated macrophages.
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Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data:
TL;DR: A theoretical model of blood–brain exchange is developed and a procedure is derived that can be used for graphing multiple-time tissue uptake data and determining whether a unidirectional transfer process was dominant during part or all of the experimental period.
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The immune-hypothalamic-pituitary-adrenal axis.
TL;DR: This review intends to examine the interactions between the immune system and the hypothalamic-pituitary-adrenal (HPA) axis and discusses products and components from theimmune system that stimulate or inhibit the HPA axis.
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Production of tumor necrosis factor-alpha by microglia and astrocytes in culture
TL;DR: Stimulation of mouse astrocytes and microglia in enriched culture by lipopolysaccharide results in the production of a cytotoxic factor that is functionally similar to macrophage-derived tumor necrosis factor-alpha (TNF) and may play a role in certain pathological conditions in the brain.
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Transport of α-Aminoisobutyric Acid across Brain Capillary and Cellular Membranes
TL;DR: These studies indicated that the transport of AIB into brain cells was approximately 110 to 265 times greater than that across normal brain capillaries per unit mass of brain tissue, and that the BBB limits blood-to-brain cell transport of this amino acid.