Erratum to: Effects of adriamycin and candesartan on the collagen and elastin of the aorta in rats
TLDR
After publication of the article, it was discovered that a citation error had occurred, resulting in different citation numbers in the PDF and HTML files, and the correct citation of 20:8 has now been updated in all versions of the manuscript.Abstract:
After publication of the article [1] it was discovered that a citation error had occurred, resulting in different citation numbers in the PDF and HTML files. The correct citation of 20:8 has now been updated in all versions of the manuscript. We apologise for any inconvenience caused by this error.read more
Citations
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Effects of adriamycin and candesartan on the collagen and elastin of the aorta in rats
TL;DR: It is suggested that adriamycin has a tendency of decreasing the quantity of elastin fibers and candesartan cannot mitigate the effects of adRIamycin on elast in fibers.
References
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The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators.
Bertram Pitt,Faiez Zannad,Willem J. Remme,Robert J. Cody,Alain Castaigne,Alfonso Perez,Jolie Palensky,Janet Wittes +7 more
TL;DR: Blockade of aldosterone receptors by spironolactone, in addition to standard therapy, substantially reduces the risk of both morbidity and death among patients with severe heart failure.
Journal ArticleDOI
Feasibility of Treating Prehypertension with an Angiotensin-Receptor Blocker
Stevo Julius,Shawna D. Nesbitt,Brent M. Egan,Michael A. Weber,Eric L. Michelson,Niko Kaciroti,Henry R. Black,Richard H. Grimm,Franz H. Messerli,Suzanne Oparil,M. Anthony Schork +10 more
TL;DR: Treatment of prehypertension with candesartan appeared to be well tolerated and reduced the risk of incident hypertension during the study period, and treatment of pre Hypertension appears to be feasible.
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The anthracyclines: will we ever find a better doxorubicin?
TL;DR: Current studies are evaluating increased doses of epirubicin to improve anthracycline cytotoxicity, while limiting cardiotoxicity, but at present DOX still reigns in this drug class as the one having the most proven cancerocidal effect.
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Elastin in large artery stiffness and hypertension
TL;DR: This review discusses how alterations in the amount, assembly, organization, or chemical properties of the elastic fibers affect arterial stiffness and blood pressure and Therapies that have a direct effect on arterIAL stiffness through alterations to the elastic fiber in the wall may be an effective treatment for essential hypertension.
Journal ArticleDOI
Endothelial nitric oxide synthase-dependent superoxide generation from adriamycin
Jeannette Vasquez-Vivar,Pavel Martásek,Neil Hogg,Bettie Sue Siler Masters,Kirkwood A. Pritchard,Balaraman Kalyanaraman +5 more
TL;DR: It is demonstrated here that the endothelial isoform of nitric oxide synthase (eNOS) reduces adriamycin to the semiquinone radical, which enhances superoxide formation and Nitric oxide production and leads eNOS to generate peroxynitrite and hydrogen peroxide, potent oxidants implicated in several vascular pathologies.