Erythrocyte Sedimentation: Collapse of a High-Volume-Fraction Soft-Particle Gel
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Using both light microscopy and mesoscale cell-level simulations, this paper showed that erythrocytes form a soft-particle gel, and the high volume fraction of erythropoietin (EPO) cells, their deformability, and weak attraction lead to unusual properties of this gel.Abstract:
The erythrocyte sedimentation rate is one of the oldest medical diagnostic methods whose physical mechanisms remain debatable today. Using both light microscopy and mesoscale cell-level simulations, we show that erythrocytes form a soft-particle gel. Furthermore, the high volume fraction of erythrocytes, their deformability, and weak attraction lead to unusual properties of this gel. A theoretical model for the gravitational collapse is developed, whose predictions are in agreement with detailed macroscopic measurements of the interface velocity. read more
Citations
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References
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Journal ArticleDOI
Random close packing of hard spheres and disks
TL;DR: In this paper, a simple definition of random close packing of hard spheres is presented, and the consequences of this definition are explored according to this definition, and lower bounds on the critical packing fraction for which the median nearest-neighbor radius equals the diameter of the spheres are obtained.
Journal ArticleDOI
Developing a new form of permeability and Kozeny-Carman constant for homogeneous porous media by means of fractal geometry
TL;DR: In this article, the authors derived an analytical expression for the permeability in homogeneous porous media based on the fractal characters of porous media and capillary model, which is expressed as a function of fractal dimensions, porosity and maximum pore size.
Journal ArticleDOI
Permeability of saturated sands, soils and clays
TL;DR: In this paper, it is shown that clays do not conform to the Kozeny theory in its simple form, but that it may be modified to give a satisfactory representation of the data available.
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