Journal ArticleDOI
Essential role of the inositol 1,4,5-trisphosphate receptor/Ca2+ release channel in Ca2+ waves and Ca2+ oscillations at fertilization of mammalian eggs.
TLDR
It is now apparent that signal transduction at fertilization is dependent on sperm-stimulated activation of phospholipase C which causes hydrolysis of phosphatidylinositol bisphosphate and production of InsP3, leading to IICR.About:
This article is published in Developmental Biology.The article was published on 1993-07-01. It has received 525 citations till now. The article focuses on the topics: Inositol trisphosphate receptor & Cortical granule exocytosis.read more
Citations
More filters
Journal ArticleDOI
The versatility and universality of calcium signalling
TL;DR: The universality of calcium as an intracellular messenger depends on its enormous versatility, which is exploited to control processes as diverse as fertilization, proliferation, development, learning and memory, contraction and secretion.
Journal ArticleDOI
Inositol Trisphosphate and Calcium Signaling
TL;DR: This InsP 3 /Ca 2+ pathway has been adapted to control processes as diverse as fertilization, proliferation, contraction, cell metabolism, vesicle and fluid secretion, and information processing in neuronal cells.
Journal ArticleDOI
PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development.
Christopher M. Saunders,Mark G. Larman,John Parrington,Llewellyn J. Cox,Jillian Royse,Lynda Blayney,Karl Swann,Francis Anthony Lai +7 more
TL;DR: A novel, sperm-specific phospholipase C, PLC zeta, that triggers Ca(2+) oscillations in mouse eggs indistinguishable from those at fertilisation is identified and it is consistent with sperm PLCZeta as the molecular trigger for development of a fertilised egg into an embryo.
Journal ArticleDOI
Comparative Biology of Calcium Signaling during Fertilization and Egg Activation in Animals
TL;DR: Findings fail to support the dichotomy in calcium signaling modes that had previously been proposed for protostomes vs deuterostomes and instead suggest that various features of fertilization-induced calcium signals are widely shared throughout the animal kingdom.
Journal ArticleDOI
Calcium signalling and cell proliferation.
TL;DR: The role of calcium in cell proliferation is highlighted by the increasing number of anticancer therapies and immunosuppressant drugs directed towards this calcium signalling pathway.
Related Papers (5)
Repetitive calcium transients and the role of calcium in exocytosis and cell cycle activation in the mouse egg.
Douglas Kline,Joanne T. Kline +1 more