Showing papers in "Developmental Biology in 1992"

TL;DR: It is demonstrated that the calcium increase at fertilization is required for cortical granule exocytosis and resumption of the cell cycle in a mammalian egg.

TL;DR: The spatio-temporal proliferation pattern of postembryonic neuroblasts in the central brain region of the supra-esophageal ganglion of Drosophila melanogaster was studied by labeling DNA replicating cells with 5-bromo-2'-deoxyuridine (BrdU).

TL;DR: The ability of the MyoD family of muscle-specific helix-loop-helix proteins to inhibit proliferation of normal as well as transformed cells from multiple lineages suggests that they interact with conserved components of the cellular machinery involved in cell cycle progression and that similar types of regulatory factors participate in differentiation and cell cycle control in diverse cell types.

TL;DR: This is a review of studies related to the concepts of myogenic cell lineage in higher vertebrate development with emphases on some of the most challenging problems of myogenesis including the embryonic origins ofMyogenic precursor cells, the mechanisms of fiber type diversity and patterning, the distinctions among myoblasts during myogenesis, and the current hypotheses of how a variety of factors, intrinsic and extrinsic to the myoblast, determine the definitive phenotype of a muscle fiber.

TL;DR: The expression of calponin, similar to the expression of alpha-SM-actin, SM-MHCs, and h-caldesmon, is developmentally regulated in aortic SMCs, demonstrating that the time course of maturation of visceral SMCs is different from that of vascular SMCs.

TL;DR: The tissue- and organ-specific overproduction of cytokinins produced a number of morphological and physiological changes, including stunting, loss of apical dominance, reduction in root initiation and growth, and adventitious shoot formation from unwounded leaf veins and petioles, altered nutrient distribution, and abnormal tissue development in stems.

TL;DR: Sequence analysis reveals that this mouse Notch gene possesses EGF repeats, Notch/lin-12 repeats, and CDC-10/SWI-6 repeats, characteristic of other Notch homologues, and Northern analysis revealed that the transcript size was roughly 10 kb as has been found for theother Notch genes.

TL;DR: Significant evidence is provided that sperm possess VDCC and that their activation is required for the Ca2+ entry that mediates acrosomal exocytosis in both the presence and the absence of egg agonists, and that VD CC activation is necessary in the ZP3 signal transduction pathway.

TL;DR: The analysis of the heart tube's sensitivity to RA and its timing suggest that polarity is established during or shortly after initial commitment to the cardiac lineage.

TL;DR: Findings suggest that determination of the myogenic cell lineage in quail somites is a progressive process controlled by influences of the neural tube on the expression of the qmf regulatory genes in newly forming somites.

TL;DR: Steel factor (SLF) is a recently identified growth factor which is the gene product of the murine Steel locus and a ligand for the c-kit tyrosine kinase receptor, the Product of the dominant white spotting locus.

TL;DR: The results suggest that the balance between cell-cell and cell-matrix adhesion may be critical for this process and that the cell adhesion molecules N-CAM and N-cadherin are important for the normal integrity of the cranial neural tube and for the emigration of neural crest cells.

TL;DR: It is concluded that early mouse embryo lungs express EGF transcripts and corresponding EGF peptides in a specific position-restricted distribution which coimmunolocalizes with EGFR in the primitive airways, while stimulatory and inhibitory studies indicate a functional role for the transduced EGF signal in the epigenetic regulation of lung branching morphogenesis.

TL;DR: The results suggest that differences in HA synthesis between subregions of membrana granulosa depend on a diffusion gradient of the oocyte factor(s).

TL;DR: Several specific questions of leaf development and especially questions as to source of inductive signals or homologies among juvenile and adult organ parts are recast in light of this "maturation schedule" hypothesis.

TL;DR: The results of the recent finding that RA can turn tail regenerates into limbs, as evidence that intercalary interactions may also be involved in the formation of the primary body axis, are interpreted.

TL;DR: While CNTF has effects on neurotransmitter properties similar to those previously reported for CDF/LIF, the actions of these two factors are differentially modulated by depolarization, suggesting that the mechanisms of cholinergic and neuropeptide induction for the two factors differ.

TL;DR: Analysis of the temporal and spatial expression patterns of the murine fibroblast growth factor receptor-1 (FGFR-1) in order to help define the role of FGFs in the processes of gastrulation and segmentation found patterns of expression are consistent with a role for FGFR- 1 in posterior mesoderm formation.

TL;DR: A complex pathway for assembly and rotation of the meiotic spindles during maturation of Xenopus oocytes is defined, suggesting that prometaphase elongation of meioticSpindles in Xenopus Oocytes results from active sliding of antiparallel microtubules.

TL;DR: The transition of the DiI-labeled cells from an epithelial phenotype to a mesenchymal phenotype is consistent with a fate of epithelial-mesenchyme transformation rather than programmed cell death.

TL;DR: Results support the idea that specific expression of the Pgk-2 gene in meiotic and postmeiotic spermatogenic cells has evolved to compensate for reduced levels of PgK-1 gene product caused by transient X-chromosome inactivation in these cells.

TL;DR: This is the first study reporting the existence and localization of complementary sites to a specific sperm protein on the plasma membrane of the mammalian egg on the basis of the presence of DE binding sites on the egg surface.

TL;DR: It is speculated that Evx-1 plays a role in the dorsoventral specification of mesodermal cell fate, based on fate-mapping studies indicating that different types of mesoderm emerge from different regions of the primitive streak and the observation that high levels of expression are localized to the region that will give rise to extraembryonic and ventral mesmoderm.

TL;DR: The pervasive nature of EGF-R expression throughout development suggests important roles for these receptors which could include autocrine and paracrine stimulation.

TL;DR: It is speculated that the epithelial dermatome may transiently produce inhibitory substances and that emerging dermis may provide a long-distance, stimulatory cue.

TL;DR: Results indicate that during the first cell cycle and prior to initiation of zygotic gene expression, the embryonic cytoplasm undergoes a transition from a transcriptionally nonpermissive to permissive state.

TL;DR: The results indicate that repetitive calcium stimuli can regulate the rate and extent of meiotic resumption and the time course of pronuclear formation during mouse oocyte activation and suggest that meiotics resumption in mammalian oocytes is regulated by the amplitude and frequency of cytosolic calcium oscillations induced by the activating stimulus.

TL;DR: The results support the concept that the periductal ECM acts as a reservoir for TGF-beta 1 that functions to maintain an open pattern of mammary branching by inhibiting ductal, but not alveolar, bud formation.

TL;DR: This review is intended to serve as a primer on the current state of the eukaryotic cell cycle regulatory model, an introduction to the special roles of cell division and its control in plant development, and a review of recent progress in applying the universal mitotic control paradigm to higher plant systems.

TL;DR: Results indicate that basement membrane can play a positive role in determining cell-specific expression of certain keratins such as K12, and speculate that in conjunctiva K3 expression is influenced by certain negative exogenous factors.