J
John Parrington
Researcher at University of Oxford
Publications - 113
Citations - 7367
John Parrington is an academic researcher from University of Oxford. The author has contributed to research in topics: Sperm & Oocyte activation. The author has an hindex of 43, co-authored 109 publications receiving 6585 citations. Previous affiliations of John Parrington include National Institute for Medical Research & University College London.
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Journal ArticleDOI
PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development.
Christopher M. Saunders,Mark G. Larman,John Parrington,Llewellyn J. Cox,Jillian Royse,Lynda Blayney,Karl Swann,Francis Anthony Lai +7 more
TL;DR: A novel, sperm-specific phospholipase C, PLC zeta, that triggers Ca(2+) oscillations in mouse eggs indistinguishable from those at fertilisation is identified and it is consistent with sperm PLCZeta as the molecular trigger for development of a fertilised egg into an embryo.
Journal ArticleDOI
NAADP mobilizes calcium from acidic organelles through two-pore channels
Peter J. Calcraft,Margarida Ruas,Zui Pan,Xiaotong Cheng,Abdelilah Arredouani,Xuemei Hao,Xuemei Hao,Jisen Tang,Katja Rietdorf,Lydia Teboul,Kai Ting Chuang,Pei-Hui Lin,Rui Xiao,Chunbo Wang,Yingmin Zhu,Yakang Lin,Christopher N. Wyatt,John Parrington,Jianjie Ma,A. Mark Evans,Antony Galione,Michael X. Zhu +21 more
TL;DR: It is shown that two-pore channels (TPCs) comprise a family of NAADP receptors, with human TPC1 and chicken TPCN3 being expressed on endosomal membranes, andhuman TPC2 on lysosome membranes when expressed in HEK293 cells, which will advance the understanding of the physiological role ofNAADP.
Journal ArticleDOI
Calcium oscillations in mammalian eggs triggered by a soluble sperm protein
TL;DR: A soluble sperm protein is identified that exhibits Ca2+ oscillation-inducing ('oscillogen') activity in eggs and may represent the physiological trigger for development in mammals.
Journal ArticleDOI
Human sperm devoid of PLC, zeta 1 fail to induce Ca2+ release and are unable to initiate the first step of embryo development
Sook-Young Yoon,Teru Jellerette,Ana M. Salicioni,Hoi Chang Lee,Myung-sik Yoo,Kevin Coward,John Parrington,Daniel Grow,Jose B. Cibelli,Pablo E. Visconti,Jesse Mager,Rafael A. Fissore +11 more
TL;DR: The results indicate that the inability of human sperm to initiate [Ca(2+)](i) oscillations leads to failure of egg activation and sterility and that abnormal PLCZ1 expression underlies this functional defect.
Journal ArticleDOI
Reduced amounts and abnormal forms of phospholipase C zeta (PLCzeta) in spermatozoa from infertile men.
Elke Heytens,John Parrington,Kevin Coward,Kevin Coward,C Young,S Lambrecht,Sook-Young Yoon,Rafael A. Fissore,R. Hamer,Charlotte M. Deane,Margarida Ruas,P Grasa,R. Soleimani,Claude Cuvelier,Jan Gerris,Marc Dhont,Dieter Deforce,Luc Leybaert,P. De Sutter +18 more
TL;DR: The findings illustrate the importance of PLCzeta during fertilization and suggest that mutant forms of P LCzeta may underlie certain types of human male infertility.