Establishment of reference values of CD4 and CD8 lymphocyte subsets in healthy Nigerian adults.
D Oladepo,E O Idigbe,Rosemary A. Audu,U S Inyang,Godwin E. Imade,A. O. Philip,Okafor Go,David O. Olaleye,S B Mohammed,N N Odunukwe,T. O. Harry,M. Edyong-Ekpa,John Idoko,Adesola Z. Musa,A. Adedeji,A. Nasidi,Y Ya'aba,K Ibrahim +17 more
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TLDR
A total of 2,570 apparently healthy human immunodeficiency virus-negative adults from the six geopolitical zones in the country were enrolled in this study in 2006 and had CD4 counts within the range of 501 to 1,000 cells/μl.Abstract:
A total of 2,570 apparently healthy human immunodeficiency virus-negative adults from the six geopolitical zones in the country were enrolled in our study in 2006. The samples were assayed using the Cyflow technique. Data were analyzed using the Statistical Package for Social Scientists (SPSS). The majority (64%) of the participants had CD4 counts within the range of 501 to 1,000 cells/μl. The reference range for CD4 was 365 to 1,571 cells/μl, while the reference range for CD8 was 145 to 884 cells/μl.read more
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One Percent Tenofovir Applied Topically to Humanized BLT Mice and Used According to the CAPRISA 004 Experimental Design Demonstrates Partial Protection from Vaginal HIV Infection, Validating the BLT Model for Evaluation of New Microbicide Candidates
Paul W. Denton,Florence A. Othieno,Francisco Martinez-Torres,Wei Zou,John F. Krisko,Elisa Fleming,Sima Zein,Daniel A. Powell,Daniel A. Powell,Angela Wahl,Youn Tae Kwak,Brett D. Welch,Michael S. Kay,Deborah A. Payne,Philippe Gallay,Ettore Appella,Jacob D. Estes,Min Lu,J. Victor Garcia +18 more
TL;DR: Evaluated the topical administration of tenofovir as used in CAPRISA 004 to prevent vaginal HIV transmission in BLT mice and demonstrates that these effective topical inhibitors have excellent potential to prevent vagina HIV Transmission in humans.
Journal ArticleDOI
Reference ranges of lymphocyte subsets in healthy adults and adolescents with special mention of T cell maturation subsets in adults of South Florida.
Ranjini Valiathan,Khaled Deeb,Marc Diamante,Margarita Ashman,Naresh Sachdeva,Deshratn Asthana +5 more
TL;DR: The need for periodic evaluation and establishment of lymphocyte reference ranges for patient population served based on gender and age since these could influence immune status and treatment outcome is indicated.
Journal ArticleDOI
Comprehensive Reference Ranges for Hematology and Clinical Chemistry Laboratory Parameters Derived from Normal Nigerian Adults
Timzing Miri-Dashe,Sophia Osawe,Monday Tokdung,Nenbammun Daniel,Rahila Pam Choji,Ille Mamman,Kurt Deme,Dapus Damulak,Alash'le Abimiku +8 more
TL;DR: Hematological and Clinical Chemistry reference ranges established in this study showed significant gender differences in apparently healthy voluntary non-remunerated blood donors and pregnant women and difference observed underscore the need to establish reference values for different populations.
Journal ArticleDOI
Outcomes of Nigeria's HIV/AIDS Treatment Program for Patients Initiated on Antiretroviral Treatment between 2004-2012
Ibrahim Dalhatu,Dennis Onotu,Solomon Odafe,Oseni Abiri,Henry Debem,Simon Agolory,Ray W. Shiraishi,Andrew F. Auld,Mahesh Swaminathan,Kainne Dokubo,Evelyn Ngige,Chukwuemeka Asadu,Emmanuel Abatta,Tedd V. Ellerbrock +13 more
TL;DR: Moderate/Advanced HIV disease was predictive of attrition; earlier ART initiation could improve program outcomes; Retention interventions targeting men and those with lower levels of education are needed.
Journal ArticleDOI
Randomization-Based Inference within Principal Strata.
TL;DR: This research is motivated by HIV prevention studies, where few infections are expected and inference is desired within the always-infected principal stratum, that is, all individuals who would become infected regardless of randomization assignment.
References
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Journal ArticleDOI
Lymphocyte subset reference ranges in adult Caucasians.
T. Reichert,M. DeBruyère,Véronique Deneys,T. Tötterman,Peter M. Lydyard,F. Yuksel,Helen Chapel,D. Jewell,L.W.A. van Hove,J. Linden,L. Buchner +10 more
TL;DR: In this article, the distributions of lymphocyte populations bearing the following antigens: CD3 (T cells), CD19 (B cells, CD4 (T helper/inducer), CD8 (T suppressor/cytotoxic and some NK cells), and CD3-, CD16+, and/or CD56+ (NK cells).
Journal ArticleDOI
Normal values of CD4 and CD8 lymphocyte subsets in healthy indian adults and the effects of sex, age, ethnicity, and smoking
TL;DR: Normal ranges of absolute and percentage values of CD4 and CD8 T‐lymphocyte subsets and the ratio of CD 4 to CD8 in normal Indian adults are provided.
Journal ArticleDOI
Do gender differences in CD4 cell counts matter
Maria Prins,J.R. Robertson,R P Brettle,Ildefonso Hernández Aguado,Barbara Broers,Faroudy Boufassa,David J. Goldberg,Robert Zangerle,R. A. Coutinho,A. van den Hoek +9 more
TL;DR: Gender differences in CD4 lymphocyte counts suggest a delay of initiation of therapy in women compared with men, and if this delay unfavourably influences progression, treatment guidelines should be revised so that women can benefit equally from HAART.
Journal ArticleDOI
Hematological reference ranges among healthy Ugandans.
S B Tugume,E M Piwowar,T Lutalo,P N Mugyenyi,Robert M. Grant,F W Mangeni,K Pattishall,Edward Katongole-Mbidde +7 more
TL;DR: Women had significantly higher mean absolute lymphocyte counts,absolute CD4 counts and absolute CD4/CD8 ratios than did men, and these reference ranges differ from those reported for populations outside Africa.
Journal ArticleDOI
Immunohematological Reference Ranges for Adults from the Central African Republic
Didier Menard,Marie Joelle Mandeng,Mesmin Bem Tothy,Eric Kassa Kelembho,Gérard Grésenguet,Antoine Talarmin +5 more
TL;DR: The WBC and hemoglobin values of healthy HIV-negative adults from the CAR are lower than the reference values currently used in the CAR and the absolute CD4 T-cell counts ofhealthy HIV- negative adults fromThe CAR are similar to values for Europeans but theabsolute CD8 T- cell counts are much higher.