Journal ArticleDOI
Ethyl substitution at the 7 position extends the half-life of 10-hydroxycamptothecin in the presence of human serum albumin
Thomas G. Burke,Zihou Mi +1 more
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This article is published in Journal of Medicinal Chemistry.The article was published on 1993-08-20. It has received 90 citations till now. The article focuses on the topics: Serum albumin & Human serum albumin.read more
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Camptothecin: current perspectives.
TL;DR: This review summarizes the current status of studies of the mechanism of action of camptothecin, including topoisomerase I inhibition and additional cellular responses, and a systematic evaluation of novel and important analogues of camPTothecin and their contribution to the current structure-activity profile are considered.
Journal ArticleDOI
Differential interactions of camptothecin lactone and carboxylate forms with human blood components.
Zihou Mi,Thomas G. Burke +1 more
TL;DR: The findings that HSA denaturation abolishes high-affinity binding indicate that interactions of the carboxylate drug form are specific for the native HSA conformation.
Journal ArticleDOI
Development and characterization of a novel liposome-based formulation of SN-38.
TL;DR: A novel, liposome-based SN-38 formulation, LE-SN38 has shown promising results in terms of increased cytotoxicity against various tumor cell lines and better therapeutic efficacy towards xenograft mouse models compared to CPT-11.
Journal ArticleDOI
Prodrug and nanomedicine approaches for the delivery of the camptothecin analogue SN38
TL;DR: This review summarizes the recent advances for the delivery of SN38 with a focus on macromolecular prodrugs and nanomedicines.
Journal ArticleDOI
Marked interspecies variations concerning the interactions of camptothecin with serum albumins: a frequency-domain fluorescence spectroscopic study.
Zihou Mi,Thomas G. Burke +1 more
TL;DR: Due to the unique capacity of human albumin to bind camptothecin carboxylate, resulting in extensive conversion of the drug to its biologically inactive form, it appears that the success of the agent in eradicating cancer in animal models may be inherently more difficult to duplicate in man.
Related Papers (5)
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.
Arrest of Replication Forks by Drug-stabilized Topoisomerase I-DNA Cleavable Complexes as a Mechanism of Cell Killing by Camptothecin
The structural basis of camptothecin interactions with human serum albumin : impact on drug stability
Thomas G. Burke,Zihou Mi +1 more