Open AccessJournal Article
Evaluation of the peripheral and central antagonistic activities against 5-hydroxytryptamine of some new agents.
C Mawson,H Whittington +1 more
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This article is published in British Journal of Pharmacology.The article was published on 1970-05-01 and is currently open access. It has received 82 citations till now. The article focuses on the topics: Serotonin Antagonists.read more
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m-Chlorophenylpiperazine: A central serotonin agonist causing powerful anorexia in rats
TL;DR: The data suggest that the decrease of food intake induced by metachlorophenylpiperazine depends on its ability to act as a serotonin agonist in the brain, which could prove an important tool for studies aimed at elucidating the functional role of serotonin in the central nervous system.
Journal ArticleDOI
Prolactin secretion in man: a useful tool to evaluate the activity of drugs on central 5-hydroxytryptaminergic neurones. Studies with fenfluramine.
TL;DR: The possibility that serum PRL levels in humans may represent a useful tool to evaluate, in vivo, the activity of drugs possessing putative 5-hydroxytryptaminergic properties is suggested.
Book ChapterDOI
Cocaine: Discussion on the Role of Dopamine in the Biochemical Mechanism of Action
TL;DR: In vivo studies have shown that cocaine induces a short-lasting uptake inhibition into brain tissues of noradrenaline, dopamine, and serotonin, which is related to its potentiating effect on biogenic amines.
Journal ArticleDOI
D- and L-isomers of fenfluramine differ markedly in their interaction with brain serotonin and catecholamines in the rat
TL;DR: The results show that the d- and l-isomers of fenfluramine at relatively low doses have a specific action on brain 5-HT and catecholamines, respectively.
Journal ArticleDOI
Evidence for two types of excitatory receptor for 5-hydroxytryptamine in dog isolated vasculature
TL;DR: The results are consistent with the hypothesis that there are two types of receptor mediating 5‐HT‐induced vasoconstriction in dog vasculature, and one of these is like the previously described ‘D‐receptor’.