Journal ArticleDOI
Examination of Self-Crosslinked Gelatin as a Hydrogel for Controlled Release
Mary M. Welz,Clyde M. Ofner +1 more
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TLDR
A gelatin matrix crosslinked by extensive dehydration was examined for use in controlled drug delivery in this preliminary investigation and the soluble, ionized form under conditions of maximum swelling and a possible drug-matrix repulsive interaction had the fastest release rate.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1992-01-01. It has received 82 citations till now. The article focuses on the topics: Controlled release & Gelatin.read more
Citations
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Journal ArticleDOI
Hydrogels: from controlled release to pH-responsive drug delivery.
TL;DR: This review highlights the use of hydrogels (a class of polymeric systems) in controlled drug delivery, and their application in stimuli- responsive, especially pH-responsive, drug release.
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Stimulus-responsive hydrogels: Theory, modern advances, and applications
TL;DR: This extensive review identifies and discusses the multitude of response modalities that have been developed, including temperature, pH, chemical, light, electro, and shear-sensitive hydrogels.
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Stimuli-responsive polymers and their applications in drug delivery.
TL;DR: This review will delve into the various internally and externally stimuli-responsive polymers and the drug delivery systems that exploit them.
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Phase separation, pore structure, and properties of nanofibrous gelatin scaffolds
Xiaohua Liu,Peter X. Ma +1 more
TL;DR: A processing technique has been developed to create 3D nanofibrous gelatin (NF-gelatin) scaffolds, which mimic both the physical architecture and the chemical composition of natural collagen, which are excellent scaffolds for tissue engineering.
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Cross-linking and characterisation of gelatin matrices for biomedical applications
A.J. Kuijpers,Gerard H.M. Engbers,Jeroen Krijgsveld,Sebastian A. J. Zaat,Jacob Dankert,Jan Feijen +5 more
TL;DR: Cross-linking of gelatin A and B with N,N-(3-dimethylaminopropyl)-N′-ethyl-carbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS) was optimised by varying the NHS/ EDC molar ratio at constant EDC concentration.
References
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Journal ArticleDOI
A simple equation for description of solute release II. Fickian and anomalous release from swellable devices
TL;DR: In this paper, an exponential relation M t /M ∞ = kt n may be used to describe the Fickian and non-Fickian release behavior of release systems which are prepared by incorporation of a drug in a hydrophilic, initially glassy polymer.
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Biological effects of residual glutaraldehyde in glutaraldehyde‐tanned collagen biomaterials
TL;DR: Observations indicate that leaching of the glutaraldehyde from glutARaldehyde-tanned collagen sponge is sufficient to produce potentially adverse cellular effects both in vivo and in vitro.
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Kinetics of drug release from hydrogel matrices
TL;DR: The kinetics of drug release from hydrogel matrices will be examined both experimentally and theoretically and special emphasis will be placed on the effect of local drug concentration on the swelling behavior ofhydrogel drug carriers.
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Cross-linking of gelatine by dehydration.
Ioannis V. Yannas,A. V. Tobolsky +1 more
TL;DR: Evidence that gelatine becomes covalently cross-linked when the water content falls below about 0.2 g/100 g protein is reported, which is of considerable value for the detailed study of physicochemical changes which accompany the excessive dehydration of proteins and nucleic acids.