Journal ArticleDOI
Examination of the effect of ethanol on human stratum corneum in vivo using infrared spectroscopy
TLDR
These findings contradict the suggestion that ethanol “disorders” the intercellular lipid bilayers of the stratum comeum and reveal that ethanol enters the skin and removes measurable quantities of the barrier material.About:
This article is published in Journal of Controlled Release.The article was published on 1991-08-01. It has received 174 citations till now. The article focuses on the topics: Stratum corneum & Absorption (skin).read more
Citations
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Journal ArticleDOI
Skin penetration enhancers.
TL;DR: It is proposed that overall the effects of CPEs on the skin barrier may best be explained by a Diffusion-Partition-Solubility theory.
Journal ArticleDOI
Transdermal drug delivery: overcoming the skin's barrier function.
TL;DR: Overcoming this barrier function then, for the purpose of transdermal drug delivery, has been a necessarily challenging task for the pharmaceutical scientist, and one that boasts significant progress.
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Lipid vesicles and other colloids as drug carriers on the skin.
TL;DR: Sufficiently stable ultra-adaptable carriers, therefore, can ensure targeted drug delivery deep below the application site, and allow highly efficient and well-tolerated drug targeting into the skin proper by means of highly adaptable drug carriers.
Journal ArticleDOI
Passive skin penetration enhancement and its quantification in vitro
TL;DR: Three different in vitro methods, specifically, classic diffusion cell studies, attenuated total-reflectance-Fourier transform infrared spectroscopy, and tape stripping in conjunction with an appropriate analytical technique, are considered, emphasizing their application to obtain quantitative values for skin transport parameters and to separate the kinetic or thermodynamic effects of an enhancement strategy.
Journal ArticleDOI
Mechanism of oleic acid-induced skin penetration enhancement in vivo in humans
TL;DR: In this article, attenuated total reflectance infrared spectroscopy was used to determine the mode of action of oleic acid (OA) in vivo, in man for a period of 16 hours.
References
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Journal ArticleDOI
Ethanol: Water mutually enhanced transdermal therapeutic system II: Skin permeation of ethanol and nitroglycerin
Bret Berner,Gerard C. Mazzenga,John H. Otte,Robert J. Steffens,Rong-Hwei Juang,Charles D. Ebert,Charles D. Ebert +6 more
TL;DR: An optimal concentration range of aqueous ethanol produces 5-10-fold increases in nitroglycerin flux across skin and ethanol skin permeation that are far greater than reported previously.
Journal ArticleDOI
Mechanism of ethanol-enhanced estradiol permeation across human skin in vivo.
TL;DR: In vivo flux of estradiol from vehicles such as PBS, ethanol, and ethanol mixtures, which minimally alter the rate-limiting barrier, can be successfully predicted with knowledge of only two physicochemical parameters, theEstradiol concentration in the vehicle and the Km of est radiol from the vehicle into isolated human stratum corneum.
Journal Article
Gel ointment of verapamil for percutaneous absorption.
Sekine T,Machida Y,Tsuneji Nagai +2 more
TL;DR: The gel ointment can be used for transdermal drug delivery when an adequate absorption promoter is added, and the effect being greatly dependent on the amount of alcohols in the formulation.