Journal ArticleDOI
Excipient and Dose per Unit Area Affect Sensitivity When Patch Testing With Gold Sodium Thiosulfate.
Dathan Hamann,Dathan Hamann,Magnus Bruze,Joseph F. Fowler,Carsten R. Hamann,Klaus Ejner Andersen,Curt Hamann +6 more
TLDR
This study determined the optimum patch test dose of gold sodium thiosulfate in a hydrogel (HYD) and established GST HYD safety/efficacy and further characterize normal morphology and time course of GST reactions.Abstract:
Background Dose/area and reading paradigms for gold patch testing are controversial and not standardized worldwide Objectives The aims of this study were to determine the optimum patch test dose of gold sodium thiosulfate (GST) in a hydrogel (HYD) and to establish GST HYD safety/efficacy and further characterize normal morphology and time course of GST reactions Methods Twenty gold-allergic patients were patch tested with a dilution series of GST HYD and with GST 2% petrolatum (pet) Furthermore, this previously determined optimal dose was compared with GST 05% pet in 19 known-allergic and 216 consecutive subjects Results The optimal GST HYD dose was 0075 mg/cm2, not statistically different from GST 2% pet (P = 04795) Gold sodium thiosulfate HYD outperformed GST 05% pet in both known-allergic subjects (79% vs 63%, P = 02482) and consecutive subjects (30% vs 9%, P < 00001) Late reactions were common in consecutive patients with both HYD and pet Significantly more persistent reactions were associated with GST HYD than with GST 05% pet Conclusions Gold sodium thiosulfate HYD 0075 mg/cm2 is the optimal dose for diagnosis of gold contact allergy with GST Gold sodium thiosulfate 05% pet yielded false-negatives in some patients, suggesting inadequate dose per centimeter squared Late reads are normal, expected, and necessary for diagnosis of gold contact allergy in this cohort (Less)read more
Citations
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Journal ArticleDOI
Contact Allergy—Emerging Allergens and Public Health Impact
TL;DR: Improved and complete ingredient labelling for all types of products, and not just as the authors have with cosmetics at present (apart from full listing of fragrance substances) in Europe, must be put on the legislative agenda.
Journal ArticleDOI
The benefit of late readings in patch testing depends both on allergen and patient characteristics.
Susann Forkel,Steffen Schubert,Heinrich Dickel,Michal Gina,Claudia Schröder-Kraft,Dieter Vieluf,Richard Brans,Burkhard Kreft,Gerda Wurpts,Johannes Geier,Timo Buhl +10 more
TL;DR: In this article, the authors investigated positive D7 reactions regarding (i) allergens in the baseline series and additional PT series of the German Contact Dermatitis Research Group (DKG) and (ii) characteristics of the patients tested.
Journal ArticleDOI
Titanium and Other Metal Hypersensitivity Diagnosed by MELISA® Test: Follow-Up Study.
Radka Vrbova,Stepan Podzimek,Lucie Himmlová,Adela Roubickova,Marketa Janovska,Tatjana Janatova,Martin Bartoš,Alex Vinsu +7 more
TL;DR: In this article, a study aimed at proving the clinical benefit of the MELISA® test in the minimization or complete elimination of health problems in patients with confirmed hypersensitivity to metals used for tissue replacements.
Journal ArticleDOI
Screening for Gold Sensitization in Consecutive Eczema Patients: Prevalence, Relevance, and Sources of Exposure.
TL;DR: Because it may be difficult to diagnose gold allergy, screening may be recommended when history taken suggests gold exposure, and relevance has been between 15% and 20% of patients.
Journal ArticleDOI
Multicenter 1-month follow-up study of the patch-test reaction to the gold sodium thiosulfate of the TRUE Test and its association with piercings and dental metal history
Kayoko Suzuki,Kayoko Matsunaga,Akiko Ito,Akiko Yagami,Takashi Ito,Hitoshi Miyazawa,Mariko Sugiura,Atsuko Adachi,Yumiko Kubota,Yuko Watanabe,Atsuko Kato,Kazue Nishioka,Atsushi Fukunaga,Masako Mochizuki,Yuko Ikezawa,Takahiko Tsunoda,Kaoru Takayama,Kumiko Washizaki,Hiroo Yokozeki,Takuma Ishihara,Hideo Asada,Hiromi Kanto +21 more
TL;DR: In this paper, a retrospective analysis was performed on 746 patients (143 male, 603 female) who were patch tested using GST of the TRUE Test, and they conducted a questionnaire on the presence of piercings or dental metals in these patients.
References
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Book
Fisher's Contact Dermatitis
TL;DR: This edition is revised and updated with all the new allergens patients are likely to encounter and includes patient education instructions for dealing with common allergens.
Journal ArticleDOI
North American Contact Dermatitis Group patch test results, 2001-2002 study period
Melanie D. Pratt,Donald V. Belsito,Vincent A. DeLeo,Joseph F. Fowler,Anthony F. Fransway,Howard I. Maibach,James G. Marks,C. G.Toby Mathias,Robert L. Rietschel,Denis Sasseville,Elizabeth F. Sherertz,Frances J. Storrs,James S. Taylor,Kathryn A. Zug +13 more
TL;DR: The findings of patch testing from January 1, 2001, to December 31, 2002 reinforce the need for a more comprehensive group of diagnostic allergens than those found in the standard screening kits.
Journal ArticleDOI
North American Contact Dermatitis Group patch-test results, 1998 to 2000.
James G. Marks,Donald V. Belsito,Vincent A. DeLeo,Joseph F. Fowler,Anthony F. Fransway,Howard I. Maibach,C. G.Toby Mathias,Melanie D. Pratt,Robert L. Rietschel,Elizabeth F. Sherertz,Frances J. Storrs,James S. Taylor +11 more
TL;DR: The findings reinforce the need for a more comprehensive group of diagnostic allergens than is found in the T.R.E.U. TEST, which is sold in the United States.
Journal ArticleDOI
Oral lesions and symptoms related to metals used in dental restorations: A clinical, allergological, and histologic study
Patrick Koch,Friedrich A. Bahmer +1 more
TL;DR: The results suggest that sensitization to mercury is an important cause of OLL, whether all lesions or only a part of them are adjacent to amalgam fillings.
Journal ArticleDOI
High frequency of contact allergy to gold sodium thiosulfate. An indication of gold allergy
TL;DR: It is suggested that a positive skin test to gold sodium thiosulfate represents gold allergy, the 2nd most common contact allergen after nickel sulfate.