Journal ArticleDOI
Expeditious synthesis and cytotoxic activity of new cyanoindolo[3,2-c]quinolines and benzimidazo[1,2-c]quinazolines.
Christelle Lamazzi,Stephane Leonce,Bruno Pfeiffer,Pierre Renard,Gérald Guillaumet,Charles W. Rees,Thierry Besson +6 more
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TLDR
Novel 6-cyanoindolo[3,2-c]quinoline and 7-cyanobenzimidazoline derivatives have been synthesised by treatment of the appropriate aromatic amines with 4.5-dichloro-1,2,3-dithiazolium chloride 1 (Appel salt).About:
This article is published in Bioorganic & Medicinal Chemistry Letters.The article was published on 2000-10-02. It has received 60 citations till now. The article focuses on the topics: Quinoline & Bicyclic molecule.read more
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A review on anticancer potential of bioactive heterocycle quinoline.
TL;DR: This review has compiled and discussed specifically the anticancer potential of quinoline derivatives, which could provide a low-height flying bird's eye view of theQuinoline derived compounds to a medicinal chemist for a comprehensive and target oriented information for development of clinically viable anticancer drugs.
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A method for the synthesis of substituted quinolines via electrophilic cyclization of 1-azido-2-(2-propynyl)benzene.
TL;DR: A new and efficient strategy for the synthesis of substituted quinolines via electrophilic cyclization is developed, and the intramolecular cyclization of 1-azido-2-(2-propynyl)benzene 1 proceeds smoothly in the presence of electrophobic reagents.
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Microwave acceleration of the Pechmann reaction on graphite/montmorillonite K10: application to the preparation of 4-substituted 7-aminocoumarins
TL;DR: In this paper, the Pechmann reaction was performed via microwave irradiation of the reactants on solid support (graphite/montmorillonite K10) for the synthesis of 7-aminocoumarins.
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Benzotriazole: An overview on its versatile biological behavior
Irene Briguglio,Sandra Piras,Paola Corona,Elisabetta Gavini,Maria Nieddu,Gianpiero Boatto,Antonio Carta +6 more
TL;DR: This review is focused on defining the place of benzotriazole derivatives in biomedical research, highlighting their versatile biological properties, the mode of action and Structure Activity Relationship (SAR) studies for a variety of antimicrobial, antiparasitic, and even antitumor, choleretic, cholesterol-lowering agents.
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Microwave-assisted Niementowski reaction. Back to the roots
TL;DR: In this article, the Niementowski synthesis of the 3H-quinazolin-4-one core was reinvestigated using microwave irradiation, and the experimental methodology and microwave conditions described here are well established, allowing significant rate enhancements and good yields compared to conventional reaction conditions.
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Two new indoloquinoline alkaloids from cryptolepis sanguinolenta: Cryptosanguinolentine and cryptotackieine
TL;DR: In this paper, the fusion of the indole and quinoline rings of C. sanguinolenta has been studied and two new indoloquinoline alkaloids are reported, one an angular indolo[3, 2-c]quinoline system and the other a linear indolo [2, 3-b] system.
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Synthesis and in vitro antitumour evaluation of benzothiazole-2-carbonitrile derivatives
TL;DR: The results show that 2-cyano derivatives exhibit a medium in vitro antitumour activity and are likely to be useful in the treatment of cancer.
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In vitro cytotoxicity of S16020-2, a new olivacine derivative.
Stéphane Léonce,Valérie Pérez,Marie-Rose Casabianca-Pignede,Monique Anstett,Emile Bisagni,Alain Pierré,Ghanem Atassi +6 more
TL;DR: The good cytotoxicity of S16020-2 against cells displaying a P-gp-mediated multidrug resistance, and its antitumor activity in vivo delineate an important chemotherapeutic potential for this drug.
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New methodology for the preparation of pyrrole and indole derivatives via iminophosphoranes:synthesis of pyrrolo[1,2-a]quinoxalines, indolo[3,2-c]quinolines and indolo[1,2-c]quinazolines
TL;DR: The aza-Wittig reaction of iminophosphorane N-[o-(triphenylphosphoranylidene)amino]-phenyl pyrrole 4 with heterocumulenes leads to functionalized pyrrolo[l,2-a]quinoxalines as discussed by the authors.