Experimental infection of layer hens with a human isolate of Brachyspira pilosicoli
TLDR
Findings confirm that B. pilosicoli strains can infect across species barriers and cause chronic mild diarrhoea in intact adult chickens.Abstract:
The anaerobic intestinal spirochaete Brachyspira pilosicoli commonly colonizes the large intestine of a number of species, including chickens and human beings. The purpose of the current study was to determine whether an isolate of B. pilosicoli recovered from an HIV-infected patient with diarrhoea could infect and cause disease in adult chickens. Over a 4-week period following experimental infection, a group of eight inoculated chickens showed a persistent and significant increase in faecal water content (∼6–7 %). The faeces of three of the eight birds became culture-positive, and remained so. At post-mortem examination, no specific pathological changes were found, and no spirochaetal attachment to the caecal epithelium was observed. These findings confirm that B. pilosicoli strains can infect across species barriers and cause chronic mild diarrhoea in intact adult chickens.read more
Citations
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Journal ArticleDOI
Oral treatment of chickens with Lactobacillus reuteri LM1 reduces Brachyspira pilosicoli-induced pathology.
Luke J. Mappley,Luke J. Mappley,Monika A. Tchórzewska,Monika A. Tchórzewska,Alejandro Núñez,Martin J. Woodward,Peter M. Bramley,Roberto M. La Ragione,Roberto M. La Ragione +8 more
TL;DR: It is shown that L. reuteri LM1 mitigates the clinical symptoms of AIS in chickens experimentally challenged with B. pilosicoli and may be a useful tool in the control of A IS.
Journal ArticleDOI
The Spirochete Brachyspira pilosicoli, Enteric Pathogen of Animals and Humans.
TL;DR: Clinicians and clinical microbiologists are encouraged to consider B. pilosicoli in their differential diagnoses and to develop and use appropriate diagnostic protocols to identify the spirochete in clinical specimens.
Journal ArticleDOI
Colonic spirochetosis in animals and humans.
TL;DR: Aalborgi and B. pilosicoli can be transferred to humans via contact with the feces of infected animals, meat from infected animals or food contaminated by food handlers as discussed by the authors.
Journal ArticleDOI
Brachyspira and its role in avian intestinal spirochaetosis.
Luke J. Mappley,Luke J. Mappley,Roberto M. La Ragione,Roberto M. La Ragione,Martin J. Woodward +4 more
TL;DR: Bans on the prophylactic use of antimicrobials in livestock are driving an urgent requirement for alternative treatment strategies for Brachyspira-related diseases, such as AIS, and the potential for the development of tools for genetic manipulation to gain an improved understanding of the pathogenesis.
Journal ArticleDOI
Evidence for systemic spread of the potentially zoonotic intestinal spirochaete Brachyspira pilosicoli in experimentally challenged laying chickens.
Luke J. Mappley,Luke J. Mappley,Monika A. Tchórzewska,Alejandro Núñez,Martin J. Woodward,Roberto M. La Ragione,Roberto M. La Ragione +6 more
TL;DR: A reproducible model of infection in point-of-lay chickens is developed and the virulence of two strains of B. pilosicoli are compared to improve understanding of the mechanisms by which Brachyspira elicit disease in poultry and in testing novel intervention strategies.
References
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Intestinal spirochete infections of chickens: a review of disease associations, epidemiology and control
C.P. Stephens,David J. Hampson +1 more
TL;DR: A recent survey of 136 layer and broiler breeder flocks in Australia revealed a high rate of infection (>40%) with intestinal spirochetes as mentioned in this paper, which was associated with wet litter problems and/or reduced egg production.
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TL;DR: It is indicated that infections with intestinal spirochaetes are a common but currently under-diagnosed cause of wet litter and/or reduced egg production in broiler breeder and layer flocks in Australia.
Journal ArticleDOI
Canine intestinal spirochetes consist of Serpulina pilosicoli and a newly identified group provisionally designated "Serpulina canis" sp. nov.
Gerald E. Duhamel,Darren J. Trott,Nagaraja Muniappa,Michelle R. Mathiesen,K. Tarasiuk,J. I. Lee,David J. Hampson +6 more
TL;DR: The data suggested the existence of a novel Serpulina species, provisionally designated “SerPulina canis,” colonizing the intestines of dogs.
Journal ArticleDOI
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TL;DR: It is suggested that heavy infestation of the gut surface epithelium by spirochaetes acts as a barrier for the normal absorptive processes and leads to diarrhoea.