Experimental infection of layer hens with a human isolate of Brachyspira pilosicoli
TLDR
Findings confirm that B. pilosicoli strains can infect across species barriers and cause chronic mild diarrhoea in intact adult chickens.Abstract:
The anaerobic intestinal spirochaete Brachyspira pilosicoli commonly colonizes the large intestine of a number of species, including chickens and human beings. The purpose of the current study was to determine whether an isolate of B. pilosicoli recovered from an HIV-infected patient with diarrhoea could infect and cause disease in adult chickens. Over a 4-week period following experimental infection, a group of eight inoculated chickens showed a persistent and significant increase in faecal water content (∼6–7 %). The faeces of three of the eight birds became culture-positive, and remained so. At post-mortem examination, no specific pathological changes were found, and no spirochaetal attachment to the caecal epithelium was observed. These findings confirm that B. pilosicoli strains can infect across species barriers and cause chronic mild diarrhoea in intact adult chickens.read more
Citations
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Journal ArticleDOI
Oral treatment of chickens with Lactobacillus reuteri LM1 reduces Brachyspira pilosicoli-induced pathology.
Luke J. Mappley,Luke J. Mappley,Monika A. Tchórzewska,Monika A. Tchórzewska,Alejandro Núñez,Martin J. Woodward,Peter M. Bramley,Roberto M. La Ragione,Roberto M. La Ragione +8 more
TL;DR: It is shown that L. reuteri LM1 mitigates the clinical symptoms of AIS in chickens experimentally challenged with B. pilosicoli and may be a useful tool in the control of A IS.
Journal ArticleDOI
The Spirochete Brachyspira pilosicoli, Enteric Pathogen of Animals and Humans.
TL;DR: Clinicians and clinical microbiologists are encouraged to consider B. pilosicoli in their differential diagnoses and to develop and use appropriate diagnostic protocols to identify the spirochete in clinical specimens.
Journal ArticleDOI
Colonic spirochetosis in animals and humans.
TL;DR: Aalborgi and B. pilosicoli can be transferred to humans via contact with the feces of infected animals, meat from infected animals or food contaminated by food handlers as discussed by the authors.
Journal ArticleDOI
Brachyspira and its role in avian intestinal spirochaetosis.
Luke J. Mappley,Luke J. Mappley,Roberto M. La Ragione,Roberto M. La Ragione,Martin J. Woodward +4 more
TL;DR: Bans on the prophylactic use of antimicrobials in livestock are driving an urgent requirement for alternative treatment strategies for Brachyspira-related diseases, such as AIS, and the potential for the development of tools for genetic manipulation to gain an improved understanding of the pathogenesis.
Journal ArticleDOI
Evidence for systemic spread of the potentially zoonotic intestinal spirochaete Brachyspira pilosicoli in experimentally challenged laying chickens.
Luke J. Mappley,Luke J. Mappley,Monika A. Tchórzewska,Alejandro Núñez,Martin J. Woodward,Roberto M. La Ragione,Roberto M. La Ragione +6 more
TL;DR: A reproducible model of infection in point-of-lay chickens is developed and the virulence of two strains of B. pilosicoli are compared to improve understanding of the mechanisms by which Brachyspira elicit disease in poultry and in testing novel intervention strategies.
References
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Journal ArticleDOI
Brachyspira (Serpulina) pilosicoli Spirochetemia in an Immunocompromised Patient
S. Kanavaki,Elpis Mantadakis,N. Thomakos,A. Pefanis,P. Matsiota-Bernard,S. Karabela,George Samonis +6 more
TL;DR: Intestinal spirochetosis should be included in the differential diagnosis of any immunocompromised or critically ill patient with dysentery, according to a recently recognized enteric pathogen of humans and animals.
Journal ArticleDOI
Light Microscopic and Ultrastructural Changes in the Ceca of Chicks Inoculated with Human and Canine Serpulina pilosicoli
TL;DR: The changes observed suggested that the mechanism of attachment of human and canine S. pilosicoli to the cecal epithelium of chicks was analogous to but different from that described previously for other attaching and effacing gastroenteric bacterial pathogens of human beings and animals.
Journal ArticleDOI
Invasive intestinal spirochetosis: A report of three cases
Vijayalakshmi Padmanabhan,Jane E. Dahlstrom,Lesley Maxwell,Graham Kaye,Anthony Clarke,Penelope J. Barratt +5 more
TL;DR: Intestinal spirochetosis, previously thought to be non‐invasive and non‐pathogenic in humans, may be invasive and may be the cause of gastrointestinal symptoms in some patients.
Journal ArticleDOI
Isolations of intestinal spirochaetes from the blood of human patients
Edith Fournié-Amazouz,G. Baranton,J.P. Carlierf,G. Chambreuil,F. Cohadon,P. Collin,A.Gougeon Jolivet,I. Hermès,C. Lernarie,I. Saint Girons +9 more
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Intestinale Spirochätose bei HIV-Infektion: Vorkommen, Isolierung und Morphologie der Spirochäten
A. Käsbohrer,H. R. Gelderblom,K. Arasteh,W. Heise,G. Grosse,M. L'age,A. Schönberg,M. A. Koch,Georg Pauli +8 more
TL;DR: The prevalence of intestinal spirochaetosis was investigated in 39 HIV-positive homosexual males in different stages of HIV infection (3 with the lymph-adenopathy syndrome, 8 with AIDS-related complex and 28 with AIDS).