Journal ArticleDOI
Falls and freezing of gait in Parkinson's disease : a review of two interconnected, episodic phenomena
TLDR
A review of the literature and the current state‐of‐the‐art suggests that clinicians should not feel deterred by the complex nature of falls and freezing of gait; a careful clinical approach may lead to an individually tailored treatment, which can offer at least partial relief for many affected patients.Abstract:
Falls and freezing of gait are two "episodic" phenomena that are common in Parkinson's disease. Both symptoms are often incapacitating for affected patients, as the associated physical and psychosocial consequences have a great impact on the patients' quality of life, and survival is diminished. Furthermore, the resultant loss of independence and the treatment costs of injuries add substantially to the health care expenditures associated with Parkinson's disease. In this clinically oriented review, we summarise recent insights into falls and freezing of gait and highlight their similarities, differences, and links. Topics covered include the clinical presentation, recent ideas about the underlying pathophysiology, and the possibilities for treatment. A review of the literature and the current state-of-the-art suggests that clinicians should not feel deterred by the complex nature of falls and freezing of gait; a careful clinical approach may lead to an individually tailored treatment, which can offer at least partial relief for many affected patients.read more
Citations
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Journal ArticleDOI
Parkinson’s disease: clinical features and diagnosis
TL;DR: A thorough understanding of the broad spectrum of clinical manifestations of PD is essential to the proper diagnosis of the disease and genetic mutations or variants, neuroimaging abnormalities and other tests are potential biomarkers that may improve diagnosis and allow the identification of persons at risk.
Journal ArticleDOI
Freezing of gait: Moving forward on a mysterious clinical phenomenon
TL;DR: Physiological, functional imaging, and clinical-pathological studies point to disturbances in frontal cortical regions, the basal ganglia, and the midbrain locomotor region as the probable origins of FoG.
Journal ArticleDOI
Gait dynamics, fractals and falls: finding meaning in the stride-to-stride fluctuations of human walking.
TL;DR: Support for the idea that gait dynamics has meaning has meaning and may be useful in providing insight into the neural control of locomotion and for enhancing functional assessment of aging, chronic disease, and their impact on mobility is discussed.
Journal ArticleDOI
Cueing training in the home improves gait-related mobility in Parkinson’s disease: the RESCUE trial
Alice Nieuwboer,Gert Kwakkel,Lynn Rochester,Derek K. Jones,E.E.H. van Wegen,A M Willems,F Chavret,V. Hetherington,Katherine Baker,I. Lim +9 more
TL;DR: Cueing training in the home has specific effects on gait, freezing and balance and may be a useful therapeutic adjunct to the overall management of gait disturbance in Parkinson’s disease.
Journal ArticleDOI
Dual tasking, gait rhythmicity, and Parkinson's disease: which aspects of gait are attention demanding?
Galit Yogev,Nir Giladi,Nir Giladi,Chava Peretz,Chava Peretz,Shmuel Springer,Ely S. Simon,Jeffrey M. Hausdorff,Jeffrey M. Hausdorff,Jeffrey M. Hausdorff +9 more
TL;DR: It is demonstrated that regulation of gait variability and rhythmicity is apparently an automatic process that does not demand attention in healthy adults, however, in patients with PD this ability becomes attention‐demanding and worsens when subjects perform secondary tasks.
References
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Journal ArticleDOI
The Activities-specific Balance Confidence (ABC) Scale
TL;DR: The greater item responsiveness of the ABC scale makes it more suitable to detect loss of balancing confidence in more highly functioning seniors, and greater situation-specificity of items may also assist clinicians in targeting appropriate interventions.
Journal ArticleDOI
Transplantation of embryonic dopamine neurons for severe Parkinson's disease.
Curt R. Freed,Paul Greene,Robert E. Breeze,Wei-Yann Tsai,William DuMouchel,Richard Kao,Sandra Dillon,Howard Winfield,Sharon Culver,John Q. Trojanowski,David Eidelberg,Stanley Fahn +11 more
TL;DR: After improvement in the first year, dystonia and dyskinesias recurred in 15 percent of the patients who received transplants, even after reduction or discontinuation of the dose of levodopa.
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Falls efficacy as a measure of fear of falling.
TL;DR: The Falls Efficacy Scale (FES) as mentioned in this paper is an instrument to measure fear of falling, based on the operational definition of this fear as "low perceived selfefficacy at avoiding falls during essential, nonhazardous activities of daily living." The reliability and validity of the FES were assessed in two samples of community living elderly persons.