Familial associations of adiposity: findings from a cross-sectional study of 12,181 parental-offspring trios from Belarus.
Rita Patel,Richard M. Martin,Michael S. Kramer,Emily Oken,Natalia Bogdanovich,Lidia Matush,George Davey Smith,Debbie A Lawlor +7 more
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TLDR
It is suggested that genetic and/or shared familial environment explain family clustering of adiposity and interventions aimed at changing overall family lifestyle are likely to be important for population level obesity prevention.Abstract:
Background
It is suggested that maternal adiposity has a stronger association with offspring adiposity than does paternal adiposity. Furthermore, a recent small study reported gender assortment in parental-offspring adiposity associations. We aimed to examine these associations in one of the largest studies to date using data from a low-middle income country that has recently undergone a major political and economic transition.
Methods and Principal Findings
In a cross-sectional study of 12,181 parental-offspring trios from Belarus (mean age (SD) of mothers 31.7 (4.9), fathers 34.1 (5.1) and children 6.6 (0.3) at time of assessment), we found positive graded associations of mother's and father's BMI with offspring adiposity. There was no evidence that these associations differed between mothers and fathers. For example, the odds ratio of offspring overweight or obesity (based on BMI) comparing obese and overweight mothers to normal weight mothers was 2.03 (95%CI 1.77, 2.31) in fully adjusted models; the equivalent result for father's overweight/obesity was 1.81 (1.58, 2.07). Equivalent results for offspring being in the top 10% waist circumference were 1.91 (1.67, 2.18) comparing obese/overweight to normal weight mothers and 1.72 (1.53, 1.95) comparing obese/overweight to normal weight fathers. Similarly, results for offspring being in the top 10% of percent fat mass were 1.58 (1.36, 1.84) and 1.76 (1.49, 2.07), for mother's and father's obese/overweight exposures respectively. There was no strong or consistent evidence of gender assortment - i.e. associations of maternal adiposity exposures with offspring outcomes were similar in magnitude for their daughters compared to equivalent associations in their sons and paternal associations were also similar in sons and daughters.
Conclusions/Significance
These findings suggest that genetic and/or shared familial environment explain family clustering of adiposity. Interventions aimed at changing overall family lifestyle are likely to be important for population level obesity prevention.read more
Citations
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Maternal pre-pregnancy BMI and gestational weight gain, offspring DNA methylation and later offspring adiposity: findings from the Avon Longitudinal Study of Parents and Children
Gemma C Sharp,Debbie A Lawlor,Rebecca C Richmond,Abigail Fraser,Andrew J Simpkin,Matthew Suderman,Hashem A. Shihab,Oliver Lyttleton,Wendy L. McArdle,Susan M. Ring,Tom R. Gaunt,George Davey Smith,Caroline L Relton +12 more
TL;DR: The data suggest that both maternal obesity and, to a larger degree, underweight affect the neonatal epigenome via an intrauterine mechanism, but weight gain during pregnancy has little effect.
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Childhood Cardiometabolic Outcomes of Maternal Obesity During Pregnancy The Generation R Study
Romy Gaillard,Eric A.P. Steegers,Liesbeth Duijts,Janine F. Felix,Albert Hofman,Oscar H. Franco,Vincent W. V. Jaddoe +6 more
TL;DR: In this article, the associations of both maternal and paternal prepregnancy body mass index (BMI) with childhood body fat distribution and cardiometabolic outcomes and explored whether any association was explained by pregnancy, birth, and childhood factors.
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Maternal adiposity—a determinant of perinatal and offspring outcomes?
TL;DR: Human studies provide evidence that maternal overweight and obesity is causally related to pregnancy complications, increased offspring weight and adiposity at birth, and the difficulties associated with delivery of large-for-gestational-age infants.
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Stronger influence of maternal than paternal obesity on infant and early childhood body mass index: the Fels Longitudinal Study.
Amy M. Linabery,Ramzi W. Nahhas,William Johnson,Audrey C. Choh,Bradford Towne,Andrew O. Odegaard,Stefan A. Czerwinski,Ellen W. Demerath +7 more
TL;DR: The relative contributions of maternal and paternal body mass index (BMI) to infant and early childhood growth, as well as the timing of such effects, have not been firmly established.
Journal ArticleDOI
The Society for Social Medicine John Pemberton Lecture 2011. Developmental overnutrition—an old hypothesis with new importance?
TL;DR: Whether mothers who are more adipose or have higher glucose levels during pregnancy may overfeed their developing infants in utero and in doing so may set them on a pathway to greater adiposity throughout their lives and whether epigenetic modification mediating any effects of maternal exposures on offspring outcomes is discussed.
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