G
Gemma C Sharp
Researcher at University of Bristol
Publications - 98
Citations - 4508
Gemma C Sharp is an academic researcher from University of Bristol. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 25, co-authored 80 publications receiving 2541 citations. Previous affiliations of Gemma C Sharp include Medical Research Council & University of Edinburgh.
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Journal ArticleDOI
DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis
Bonnie R. Joubert,Janine F. Felix,Paul Yousefi,Kelly M. Bakulski,Allan C. Just,Carrie V. Breton,Sarah E. Reese,Christina A. Markunas,Christina A. Markunas,Rebecca C Richmond,Cheng-Jian Xu,Leanne K. Küpers,Sam S. Oh,Cathrine Hoyo,Olena Gruzieva,Cilla Söderhäll,Lucas A. Salas,Nour Baïz,Hongmei Zhang,Johanna Lepeule,Carlos Ruiz,Symen Ligthart,Tianyuan Wang,Jack A. Taylor,Liesbeth Duijts,Gemma C Sharp,Soesma A Jankipersadsing,Roy Miodini Nilsen,Ahmad Vaez,Ahmad Vaez,M. Daniele Fallin,Donglei Hu,Augusto A. Litonjua,Bernard F. Fuemmeler,Karen Huen,Juha Kere,Inger Kull,Monica Cheng Munthe-Kaas,Ulrike Gehring,Mariona Bustamante,Marie José Saurel-Coubizolles,Bilal M. Quraishi,Jie Ren,Jörg Tost,Juan R. González,Marjolein J. Peters,Siri E. Håberg,Zongli Xu,Joyce B. J. van Meurs,Tom R. Gaunt,Marjan Kerkhof,Eva Corpeleijn,Andrew P. Feinberg,Celeste Eng,Andrea A. Baccarelli,Sara E. Benjamin Neelon,Asa Bradman,Simon Kebede Merid,Anna Bergström,Zdenko Herceg,Hector Hernandez-Vargas,Bert Brunekreef,Mariona Pinart,Barbara Heude,Susan Ewart,Jin Yao,Nathanaël Lemonnier,Oscar H. Franco,Michael C. Wu,Albert Hofman,Albert Hofman,Wendy L. McArdle,Pieter van der Vlies,Fahimeh Falahi,Matthew W. Gillman,Lisa F. Barcellos,Ashok Kumar,Ashok Kumar,Ashok Kumar,Magnus Wickman,Magnus Wickman,Stefano Guerra,Marie-Aline Charles,John W. Holloway,Charles Auffray,Henning Tiemeier,George Davey Smith,Dirkje S. Postma,Marie-France Hivert,Brenda Eskenazi,Martine Vrijheid,Hasan Arshad,Josep M. Antó,Abbas Dehghan,Wilfried Karmaus,Isabella Annesi-Maesano,Jordi Sunyer,Akram Ghantous,Göran Pershagen,Nina Holland,Susan K. Murphy,Dawn L. DeMeo,Esteban G. Burchard,Christine Ladd-Acosta,Harold Snieder,Wenche Nystad,Gerard H. Koppelman,Caroline L Relton,Vincent W. V. Jaddoe,Allen J. Wilcox,Erik Melén,Erik Melén,Stephanie J. London +112 more
TL;DR: This large scale meta-analysis of methylation data identified numerous loci involved in response to maternal smoking in pregnancy with persistence into later childhood and provide insights into mechanisms underlying effects of this important exposure.
Journal ArticleDOI
Collider bias undermines our understanding of COVID-19 disease risk and severity
Gareth J Griffith,Tim T Morris,Matthew J. Tudball,Annie Herbert,Giulia Mancano,Lindsey Pike,Gemma C Sharp,Jonathan A C Sterne,Tom Palmer,George Davey Smith,Kate Tilling,Luisa Zuccolo,Neil M Davies,Neil M Davies,Gibran Hemani +14 more
TL;DR: The challenge of interpreting observational evidence from non-representative samples used to identify risk factors for infection with SARS-CoV-2 and COVID-19 disease outcomes is highlighted.
Posted ContentDOI
Collider bias undermines our understanding of COVID-19 disease risk and severity
Gareth J Griffith,Tim T Morris,Matt J Tudball,Annie Herbert,Giulia Mancano,Lindsey Pike,Gemma C Sharp,Tom Palmer,George Davey Smith,Kate Tilling,Luisa Zuccolo,Neil M Davies,Gibran Hemani +12 more
TL;DR: The challenge of interpreting observational evidence from samples of the population, which may be affected by collider bias, is highlighted using data from the UK Biobank in which individuals tested for COVID-19 are highly selected for a wide range of genetic, behavioural, cardiovascular, demographic, and anthropometric traits.
Journal ArticleDOI
Maternal pre-pregnancy BMI and gestational weight gain, offspring DNA methylation and later offspring adiposity: findings from the Avon Longitudinal Study of Parents and Children
Gemma C Sharp,Debbie A Lawlor,Rebecca C Richmond,Abigail Fraser,Andrew J Simpkin,Matthew Suderman,Hashem A. Shihab,Oliver Lyttleton,Wendy L. McArdle,Susan M. Ring,Tom R. Gaunt,George Davey Smith,Caroline L Relton +12 more
TL;DR: The data suggest that both maternal obesity and, to a larger degree, underweight affect the neonatal epigenome via an intrauterine mechanism, but weight gain during pregnancy has little effect.
Journal ArticleDOI
Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium
Gemma C Sharp,Gemma C Sharp,Lucas A. Salas,Lucas A. Salas,Claire Monnereau,Claire Monnereau,Catherine Allard,Paul Yousefi,Todd M. Everson,Jon Bohlin,Zongli Xu,Rae-Chi Huang,Sarah E. Reese,Cheng-Jian Xu,Nour Baïz,Cathrine Hoyo,Golareh Agha,Ritu Roy,Ritu Roy,John W. Holloway,Akram Ghantous,Simon Kebede Merid,Kelly M. Bakulski,Leanne K. Küpers,Hongmei Zhang,Rebecca C Richmond,Christian M. Page,Liesbeth Duijts,Liesbeth Duijts,Rolv T. Lie,Phillip E. Melton,Judith M. Vonk,Ellen A. Nohr,ClarLynda R. Williams-DeVane,Karen Huen,Sheryl L. Rifas-Shiman,Carlos Ruiz-Arenas,Semira Gonseth,Semira Gonseth,Faisal I. Rezwan,Zdenko Herceg,Sandra Ekström,Lisa A. Croen,Fahimeh Falahi,Patrice Perron,Margaret R. Karagas,Bilal M. Quraishi,Matthew Suderman,Maria C. Magnus,Maria C. Magnus,Vincent W. V. Jaddoe,Vincent W. V. Jaddoe,Jack A. Taylor,Jack A. Taylor,Denise Anderson,Shanshan Zhao,Henriette A. Smit,Michele J. Josey,Michele J. Josey,Asa Bradman,Andrea A. Baccarelli,Mariona Bustamante,Siri E. Håberg,Göran Pershagen,Göran Pershagen,Irva Hertz-Picciotto,Craig J. Newschaffer,Eva Corpeleijn,Luigi Bouchard,Debbie A Lawlor,Rachel L. Maguire,Lisa F. Barcellos,George Davey Smith,Brenda Eskenazi,Wilfried Karmaus,Carmen J. Marsit,Marie-France Hivert,Marie-France Hivert,Harold Snieder,M. Daniele Fallin,Erik Melén,Erik Melén,Erik Melén,Monica Cheng Munthe-Kaas,Monica Cheng Munthe-Kaas,S. Hasan Arshad,S. Hasan Arshad,Joseph L. Wiemels,Isabella Annesi-Maesano,Martine Vrijheid,Emily Oken,Nina Holland,Susan K. Murphy,Thorkild I. A. Sørensen,Thorkild I. A. Sørensen,Thorkild I. A. Sørensen,Gerard H. Koppelman,John P. Newnham,Allen J. Wilcox,Wenche Nystad,Stephanie J. London,Janine F. Felix,Janine F. Felix,Caroline L Relton +103 more
TL;DR: In this article, the association between pre-pregnancy maternal BMI and methylation at over 450,000 sites in newborn blood DNA, across 19 cohorts (9,340 mother-newborn pairs).