Journal ArticleDOI
Fetal and Neonatal Development of the Microsomal Monooxygenase System
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TLDR
In this paper, the fetal and neonatal development of the Microsomal Monooxygenase System (MOMOS) is discussed. But the authors do not discuss the role of the MOMOS in the development of infants.Abstract:
(1976). Fetal and Neonatal Development of the Microsomal Monooxygenase System. Drug Metabolism Reviews: Vol. 5, No. 1, pp. 1-42.read more
Citations
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Biotransformation of xenobiotics in the fetus
TL;DR: It seems that many hydrolytic as well as conjugative reactions are active in human fetal liver, and several activation reactions have been uncovered and they may have important implications with respect to fetal toxicology, teratology and transplacental carcinogenesis.
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Drug metabolism by the human fetus.
TL;DR: The data tend to suggest that humans and subhuman primates may be more vulnerable than the smaller common experimental animals to the toxic effects of foreign organic chemicals during prenatal life and should be weighed whenever exposure of pregnant women to such agents is contemplated.
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Identification of the major cytochrome P-450 form transplacentally induced in neonatal rabbits by 3,3,7,8-tetrachlorodibenzo-p-dioxin.
TL;DR: It is demonstrated that microsomal metabolism in TCDD-treated newborn rabbits reflects the catalytic properties of the predominant cytochrome P450 species, which is form 6.
References
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THE USE OF LEAD CITRATE AT HIGH pH AS AN ELECTRON-OPAQUE STAIN IN ELECTRON MICROSCOPY
TL;DR: The stain reported here differs from previous alkaline lead stains in that the chelating agent, citrate, is in sufficient excess to sequester all lead present, and is less likely to contaminate sections.
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The Carbon Monoxide-binding Pigment of Liver Microsomes I. EVIDENCE FOR ITS HEMOPROTEIN NATURE
Tsuneo Omura,Ryo Sato +1 more
TL;DR: The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
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Improvements in epoxy resin embedding methods.
TL;DR: Epoxy embedding methods of Glauert and Kushida have been modified so as to yield rapid, reproducible, and convenientembedding methods for electron microscopy.
Journal Article
Pharmacological implications of microsomal enzyme induction
TL;DR: It is of considerable interest that certain inducers of liver microsomal enzymes have recently been used therapeutically for the treatment of hyperbilirubinemia in jaundiced children and for thetreatment of Cushing's syndrome.
Journal ArticleDOI
Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds.
TL;DR: Whether a given aromatic or olefinic compound produces such an effect would depend on a variety of factors, such as the relative rate of formation and degradation of the intermediate oxirane, on its stability with respect to spontaneous isomerization to the corresponding phenol and on its chemical electrophilic reactivity.
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