Fish oil-derived fatty acids, docosahexaenoic acid and docosapentaenoic acid, and the risk of acute coronary events: the Kuopio ischaemic heart disease risk factor study.
TLDR
The data provide further confirmation for the concept that fish oil–derived fatty acids reduce the risk of acute coronary events, however, a high mercury content in fish could attenuate this protective effect.Abstract:
Background—Previous findings concerning the serum levels of fish-derived (n-3) fatty acids and coronary heart disease are inconsistent The purpose of this study was to investigate the association between the serum n-3 end-product fatty acids docosahexaenoic acid (DHA), docosapentaenoic acid (DPA), and eicosapentaenoic acid and the risk of acute coronary events in middle-aged men Methods and Results—We studied this association in the Kuopio Ischaemic Heart Disease Risk Factor Study, a prospective population study in Eastern Finland Subjects were randomly selected and included 1871 men aged 42 to 60 years who had no clinical coronary heart disease at baseline examination A total of 194 men had a fatal or nonfatal acute coronary event during follow-up In a Cox proportional hazards’ model adjusting for other risk factors, men in the highest fifth of the proportion of serum DHA+DPA in all fatty acids had a 44% reduced risk (P=0014) of acute coronary events compared with men in the lowest fifth Men in thread more
Citations
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Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease
TL;DR: Evidence from epidemiological studies and RCTs will be reviewed, and recommendations reflecting the current state of knowledge will be made with regard to both fish consumption and omega-3 fatty acid (plant- and marine-derived) supplementation.
Journal ArticleDOI
Fish Intake, Contaminants, and Human Health: Evaluating the Risks and the Benefits
Dariush Mozaffarian,Eric B. Rimm +1 more
TL;DR: For major health outcomes among adults, the benefits of fish intake exceed the potential risks, and for women of childbearing age, benefits of modest fish intake, excepting a few selected species, also outweigh risks.
Journal ArticleDOI
Essential fatty acids in health and chronic disease
TL;DR: Alpha-linolenic acid, found in green leafy vegetables, flaxseed, rapeseed, and walnuts, desaturates and elongates in the human body to EPA and DHA and by itself may have beneficial effects in health and in the control of chronic diseases.
Journal ArticleDOI
Optimal diets for prevention of coronary heart disease.
Frank B. Hu,Walter C. Willett +1 more
TL;DR: Substantial evidence indicates that diets using nonhydrogenated unsaturated fats as the predominant form of dietary fat, whole grains as the main form of carbohydrates, an abundance of fruits and vegetables, and adequate omega-3 fatty acids can offer significant protection against CHD.
Journal ArticleDOI
Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events.
TL;DR: Overall, current data provide strong concordant evidence that n-3 PUFA are bioactive compounds that reduce risk of cardiac death.
References
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Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial
TL;DR: Dietary supplementation with n-3 PUFA led to a clinically important and statistically significant benefit and vitamin E had no benefit and its effects on fatal cardiovascular events require further exploration.
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Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (dart)
Michael Leslie Burr,J. F. Gilbert,R. M. Holliday,Peter Creighton Elwood,Ann M. Fehily,S. Rogers,P. M. Sweetnam,N. M. Deadman +7 more
TL;DR: A modest intake of fatty fish (two or three portions per week) may reduce mortality in men who have recovered from MI.
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The inverse relation between fish consumption and 20-year mortality from coronary heart disease.
TL;DR: It is concluded that the consumption of as little as one or two fish dishes per week may be of preventive value in relation to coronary heart disease.
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Fish Consumption and Risk of Sudden Cardiac Death
Christine M. Albert,Charles H. Hennekens,Christopher J. O'Donnell,Umed A. Ajani,Vincent J. Carey,Walter C. Willett,Jeremy N. Ruskin,JoAnn E. Manson +7 more
TL;DR: Consumption of fish at least once per week may reduce the risk of sudden cardiac death in men, and fish consumption was associated with a significantly reduced risk of total mortality.
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The composition of food consumed by Greenland Eskimos.
H O Bang,Jørn Dyerberg,N Hjøorne +2 more
TL;DR: Food specimens have been collected from Greenland Eskimo hunters and their wives, in all seven persons, on seven consecutive days, and their food was found to contain more protein and less carbohydrates than average Danish food and an almost equal amount of fat.