Formation, Prevention, and Repair of DNA Damage by Iron/Hydrogen Peroxide
Ernst S. Henle,Stuart Linn +1 more
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The cytotoxic effects of O2 .About:
This article is published in Journal of Biological Chemistry.The article was published on 1997-08-01 and is currently open access. It has received 575 citations till now. The article focuses on the topics: DNA damage & Hydrogen peroxide.read more
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Oxyradicals and DNA damage
TL;DR: The levels of oxidative DNA damage reported in many human tissues or in animal models of carcinogenesis exceed the levels of lesions induced by exposure to exogenous carcinogenic compounds, and it seems likely that oxidativeDNA damage is important in the etiology of many human cancers.
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A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding
TL;DR: In this review, primary attention is given to the antioxidant (and prooxidant) activity of polyphenols arising from their interactions with iron both in vitro and in vivo.
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Oxidative Decay of DNA
Kenneth B. Beckman,Bruce N. Ames +1 more
TL;DR: A proliferation of techniques has resulted in the confirmation of the early hypotheses and also delivered some surprises in the study of DNA oxidation, and some of the most interesting recent results are outlined.
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Mechanisms of DNA damage, repair, and mutagenesis.
TL;DR: This introductory review will delineate mechanisms of DNA damage and the counteracting repair/tolerance pathways to provide insights into the molecular basis of genotoxicity in cells that lays the foundation for subsequent articles in this issue.
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Endogenous DNA damage in humans: a review of quantitative data
TL;DR: A list of endogenous DNA-damaging agents, processes and DNA adduct levels is presented and the respective roles of endogenous versus exogenous DNA damage in carcinogenesis are discussed.
References
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Book
Advanced Inorganic Chemistry
TL;DR: Cotton and Wilkinson's Advanced Inorganic Chemistry (AIC) as discussed by the authors is one of the most widely used inorganic chemistry books and has been used for more than a quarter century.
Book
The Metabolic and Molecular Bases of Inherited Disease
TL;DR: In this paper, the authors present a list of disorders of MITOCHONDRIAL FUNCTION, including the following: DISORDERS OF MIOCHONDRIC FERTILITY XIX, XVI, XIX.
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Instability and decay of the primary structure of DNA
TL;DR: The spontaneous decay of DNA is likely to be a major factor in mutagenesis, carcinogenesis and ageing, and also sets limits for the recovery of DNA fragments from fossils.
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Superoxide Radical and Superoxide Dismutases
TL;DR: O2- oxidizes the [4Fe-4S] clusters of dehydratases, such as aconitase, causing-inactivation and release of Fe(II), which may then reduce H2O2 to OH- +OH..