Journal ArticleDOI
Foveal cone pigment density difference and reflectance in retinitis pigmentosa
TLDR
Compared with similar-aged normal subjects, most patients with dominantly inherited RP had normal or minimally reduced cone pigment density difference within the central fovea, relatively lower than normal density difference at the foveal margin, and increased foveAL reflectance.Abstract:
• Cone pigment density difference refers to a change in light absorption by cones before and after bleaching of their visual pigments. With a television ophthalmoscope image processor, we measured the foveal cone pigment density difference in patients with retinitis pigmentosa (RP), good central vision, and no clinically apparent foveal lesion. Foveal reflectance was obtained at 12 different wavelengths of illumination. Compared with similar-aged normal subjects, most patients with dominantly inherited RP had normal or minimally reduced cone pigment density difference within the central fovea, relatively lower than normal density difference at the foveal margin, and increased foveal reflectance. Compared with these normal subjects, patients with recessively inherited RP had significantly reduced cone pigment density difference within the central fovea, relatively more normal density difference at the foveal margin, and normal foveal reflectance.read more
Citations
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Journal Article
Macular Pigment and Lutein Supplementation in Retinitis Pigmentosa and Usher Syndrome
Tomas S. Aleman,Jacque L. Duncan,Michelle L. Bieber,Elaine de Castro,Daniel A. Marks,Leigh M. Gardner,Janet D. Steinberg,Artur V. Cideciyan,Maureen G. Maguire,Samuel G. Jacobson +9 more
TL;DR: There was no change in central vision after 6 months of lutein supplementation, but long-term influences on the natural history of these retinal degenerations require further study.
Journal ArticleDOI
Human macular pigment assessed by imaging fundus reflectometry.
TL;DR: An analysis of spectral reflectances indicated that differences in short-wavelength reflectance between the foveal center and parafovea were influenced by spatial variations in melanin and oxyhemoglobin absorption as well as by the distribution of macular pigment.
Journal ArticleDOI
Reflectometry with a scanning laser ophthalmoscope
TL;DR: With noninvasive techniques to optimize reflectometry measurements, particularly retinal densitometry, which measures the photopigment density difference, unwanted scattered light is greatly reduced, and the retina is visualized during measurements.
Journal Article
Density of foveal cone pigments at older age.
TL;DR: It is argued that a reduction in the number of cones with age, rather than an increase in ocular stray light is the most likely explanation of the findings.
Journal ArticleDOI
Relationship between foveal cone structure and clinical measures of visual function in patients with inherited retinal degenerations.
TL;DR: Direct, objective measures of cone structure may be more sensitive indicators of disease severity than VA or foveal sensitivity in eyes with inherited retinal degenerations.
References
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Journal ArticleDOI
Autosomal dominant retinitis pigmentosa. A method of classification.
TL;DR: Four types of autosomal dominant retinitis pigmentosa were discernible in 84 patients by clinical, electrophysiologic, and psychophysical criteria, and the classification of dominantly inherited RP is important for studies of natural history in disease progression, for patient counseling, and for various laboratory investigations of patients with RP.
Journal Article
Color matching and Stiles-Crawford effect in central serous choroidopathy.
Smith Vc,Pokorny J,Diddie Kr +2 more
TL;DR: The type III color defect accompanied by pseudo-protanomaly ascribable to receptor disorientation as occurs in central serous choroidopathy may be differentiated from the type III defect without pseudo-Protanomaly.
Journal ArticleDOI
Lack of uniformity in colour matching.
TL;DR: Individual differences in matching among normal (as well as among both varieties of red‐‐green anomalous) trichromats, on the other hand, suggest that the extinction spectra of the cone pigments sensitive to long and medium wave lengths may differ from one trichromaat to the next.
Journal ArticleDOI
Bilateral symmetry of vision disorders in typical retinitis pigmentosa.
TL;DR: A very high degree of interocular congruence is observed in the patterns of both kinetic visual field defects and threshold profiles and in abnormalities of foveal colour discrimination and visual acuity in patients with retinitis pigmentosa.
Journal Article
The Stiles-Crawford effect in retinitis pigmentosa.
TL;DR: Stiles-Crawford functions were obtained from the maculas of 22 patients with different genetic types of retinitis pigmentosa and visual acuity of 20/40 or better and reduced cone directional sensitivity was seen in the fovea with both focal cone electroretinographic testing and psychophysical testing.