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Open AccessJournal ArticleDOI

Free-radical oxidation (peroxidation) products in plasma in normal and abnormal pregnancy

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TLDR
There was a significant progressive rise of two groups of free-radical oxidation products throughout pregnancy and a significantly greater rise in PET and in women whose diastolic blood pressure rose to above 70 mmHg.
Abstract
Using recently developed methods for measuring free-radical oxidation products in biological material, plasma extracts were studied in 24 women in the first two trimesters of pregnancy, in 124 women in the third trimester of pregnancy, in 20 women with pre-eclamptic toxaemia (PET), and in a control group. There was a significant progressive rise of two groups of free-radical oxidation products throughout pregnancy and a significantly greater rise in PET. In women whose diastolic blood pressure rose to above 70 mmHg there was a highly significant relation between two groups of free-radical reaction products and blood pressure.

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References
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Journal ArticleDOI

Tissue sulfhydryl groups

TL;DR: A water-soluble (at pH 8) aromatic disulfide [5,5′-dithiobis(2-nitrobenzoic acid] has been synthesized and shown to be useful for determination of sulfhydryl groups.

Tissue sulphydryl groups

G L Ellman
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Journal ArticleDOI

The thiobarbituric acid reaction and the autoxidations of polyunsaturated fatty acid methyl esters.

TL;DR: The mechanism of oxidation of methylene-interrupted trienes, tetraenes, pentaenes, and hexaenes postulates an additional step in chain propagation involving intramolecular rearrangement of the hydroperoxy free radical to a free radical bearing a closed five-membered ring peroxide.
Journal ArticleDOI

Mechanism for irreversible self-deactivation of prostaglandin synthetase.

TL;DR: A mechanism has been devised which accounts for the self-deactivation phenomenon, the effect of phenol and methional, the disulfide at the active site, and the pathway of substrate oxygenation.
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